pI: 9.8232 |
Length (AA): 746 |
MW (Da): 83884 |
Paralog Number:
75
Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 4 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
15 | 282 | 4ol8 (B) | 210 | 473 | 32.00 | 0 | 1 | 0.735832 | -0.03 |
216 | 268 | 4ol8 (A) | 407 | 459 | 37.00 | 0 | 0.72 | 0.0852409 | 1.23 |
417 | 564 | 1asu (A) | 55 | 205 | 24.00 | 0 | 0.96 | 0.517758 | -0.6 |
437 | 575 | 3kks (A) | 69 | 203 | 28.00 | 0 | 0.99 | 0.530677 | -0.1 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Ortholog group members (OG5_126567)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | ArthMp074 | hypothetical protein |
Arabidopsis thaliana | ArthMp075 | hypothetical protein |
Arabidopsis thaliana | AT4G13320 | hypothetical protein |
Candida albicans | CaO19.14099 | similar to reverse transcripases |
Candida albicans | CaO19.2164 | polyprotein of gypsy-like retrotransposon Tca3 |
Candida albicans | CaO19.2219 | polyprotein of gypsy-like retrotransposon Tca3 |
Candida albicans | CaO19.12173 | Potential retroviral integrase |
Candida albicans | CaO19.9710 | polyprotein of gypsy-like retrotransposon Tca3 |
Candida albicans | CaO19.6807 | similar to reverse transcripases |
Candida albicans | CaO19.9764 | polyprotein of gypsy-like retrotransposon Tca3 |
Caenorhabditis elegans | CELE_F40F12.9 | Protein F40F12.9, isoform B |
Dictyostelium discoideum | DDB_G0294254 | hypothetical protein |
Dictyostelium discoideum | DDB_G0294256 | hypothetical protein |
Dictyostelium discoideum | DDB_G0281535 | hypothetical protein |
Dictyostelium discoideum | DDB_G0270954 | hypothetical protein |
Dictyostelium discoideum | DDB_G0294360 | hypothetical protein |
Dictyostelium discoideum | DDB_G0294164 | hypothetical protein |
Dictyostelium discoideum | DDB_G0267362 | hypothetical protein |
Dictyostelium discoideum | DDB_G0267306 | hypothetical protein |
Dictyostelium discoideum | DDB_G0267366 | hypothetical protein |
Dictyostelium discoideum | DDB_G0294320 | hypothetical protein |
Dictyostelium discoideum | DDB_G0267356 | hypothetical protein |
Dictyostelium discoideum | DDB_G0294228 | hypothetical protein |
Dictyostelium discoideum | DDB_G0294338 | hypothetical protein |
Dictyostelium discoideum | DDB_G0294358 | hypothetical protein |
Dictyostelium discoideum | DDB_G0294322 | hypothetical protein |
Echinococcus granulosus | EgrG_000332600 | RNA directed DNA polymerase reverse transcriptase |
Echinococcus granulosus | EgrG_002036400 | retrotransposable element Tf2 155 kDa protein |
Echinococcus granulosus | EgrG_000519700 | KRAB A domain containing protein |
Echinococcus granulosus | EgrG_000078300 | RNA directed DNA polymerase reverse transcriptase |
Echinococcus granulosus | EgrG_000864400 | RNA directed DNA polymerase reverse transcriptase |
Echinococcus granulosus | EgrG_000276900 | KRAB A domain containing protein |
Echinococcus granulosus | EgrG_002029200 | KRAB A domain containing protein |
Echinococcus granulosus | EgrG_002065700 | KRAB A domain containing protein |
Echinococcus granulosus | EgrG_002017100 | RNA directed DNA polymerase reverse transcriptase |
Echinococcus multilocularis | EmuJ_000696200 | RNA directed DNA polymerase (reverse transcriptase) |
Echinococcus multilocularis | EmuJ_001177800 | RNA directed DNA polymerase (reverse transcriptase) |
Echinococcus multilocularis | EmuJ_000835700 | KRAB-A domain-containing protein |
Echinococcus multilocularis | EmuJ_000971200 | RNA directed DNA polymerase (reverse transcriptase) |
Echinococcus multilocularis | EmuJ_000519700 | KRAB A domain containing protein |
Echinococcus multilocularis | EmuJ_000696300 | RNA directed DNA polymerase (reverse transcriptase) |
Echinococcus multilocularis | EmuJ_000344300 | KRAB A domain containing protein |
Echinococcus multilocularis | EmuJ_000420600 | RNA directed DNA polymerase (reverse transcriptase) |
Echinococcus multilocularis | EmuJ_000798400 | RNA directed DNA polymerase (reverse transcriptase) |
Echinococcus multilocularis | EmuJ_000971300 | RNA directed DNA polymerase (reverse transcriptase) |
Echinococcus multilocularis | EmuJ_000078300 | RNA directed DNA polymerase (reverse transcriptase) |
Echinococcus multilocularis | EmuJ_001192700 | RNA directed DNA polymerase (reverse transcriptase) |
Echinococcus multilocularis | EmuJ_000405900 | RNA directed DNA polymerase (reverse transcriptase) |
Echinococcus multilocularis | EmuJ_001192800 | RNA directed DNA polymerase (reverse transcriptase) |
Echinococcus multilocularis | EmuJ_000421100 | RNA directed DNA polymerase (reverse transcriptase) |
Echinococcus multilocularis | EmuJ_000332600 | RNA directed DNA polymerase (reverse transcriptase) |
Echinococcus multilocularis | EmuJ_000806700 | KRAB A domain containing protein |
Echinococcus multilocularis | EmuJ_000201800 | RNA directed DNA polymerase (reverse transcriptase) |
Leishmania braziliensis | LbrM.29.2060 | hypothetical protein |
Oryza sativa | 4335122 | Os04g0191000 |
Oryza sativa | 4346512 | Os09g0250500 |
Oryza sativa | 4351358 | Os12g0121200 |
Oryza sativa | 4326584 | Os01g0640000 |
Oryza sativa | 4338193 | Os05g0241900 |
Oryza sativa | 4341086 | Os06g0493000 |
Oryza sativa | 4352106 | Os12g0428300 |
Oryza sativa | 4332571 | Os03g0300700 |
Oryza sativa | 9268490 | Os10g0383200 |
Oryza sativa | 4350106 | Os11g0224300 |
Oryza sativa | 4343440 | Os07g0528900 |
Oryza sativa | 9269336 | Os09g0321300 |
Oryza sativa | 4335669 | Os04g0389000 |
Oryza sativa | 4340711 | Os06g0266100 |
Oryza sativa | 4346466 | Os09g0135100 |
Oryza sativa | 9272273 | Os08g0123950 |
Oryza sativa | 4329502 | Os02g0522000 |
Oryza sativa | 9268521 | Os07g0148400 |
Oryza sativa | 4350342 | Os11g0305400 |
Oryza sativa | 4332963 | Os03g0377400 |
Oryza sativa | 4333099 | Os03g0411900 |
Oryza sativa | 4343355 | Os07g0510800 |
Oryza sativa | 4342054 | Os06g0713500 |
Oryza sativa | 4345730 | Os08g0451600 |
Oryza sativa | 4335375 | Os04g0283700 |
Oryza sativa | 4336900 | Os04g0603800 |
Oryza sativa | 4347442 | Os09g0491900 |
Oryza sativa | 4344745 | Os08g0164800 |
Oryza sativa | 9269300 | Os12g0194000 |
Oryza sativa | 4345263 | Os08g0321500 |
Oryza sativa | 9271085 | Os10g0322250 |
Oryza sativa | 9269157 | Os05g0263200 |
Oryza sativa | 4348294 | Os10g0317000 |
Oryza sativa | 4331616 | Os03g0147100 |
Oryza sativa | 9266908 | Os12g0142900 |
Oryza sativa | 4337440 | Os04g0682600 |
Saccharomyces cerevisiae | YGR109W-B | gag-pol fusion protein |
Saccharomyces cerevisiae | YGR109W-A | gag protein |
Saccharomyces cerevisiae | YIL082W-A | gag-pol fusion protein |
Schistosoma japonicum | Sjp_0081750 | Transposon Ty3-I Gag-Pol polyprotein, putative |
Schistosoma japonicum | Sjp_0118750 | Transposon Ty3-G Gag-Pol polyprotein, putative |
Schistosoma japonicum | Sjp_0051360 | Retrovirus-related Pol polyprotein from transposon 17.6 [Includes: Protease, putative |
Schistosoma japonicum | Sjp_0082490 | similar to Uncharacterized protein F44E2.2, putative |
Schistosoma japonicum | Sjp_0017040 | similar to Uncharacterized protein F44E2.2, putative |
Schistosoma japonicum | Sjp_0115710 | Retrovirus-related Pol polyprotein from transposon 17.6 [Includes: Protease, putative |
Schistosoma japonicum | Sjp_0019320 | similar to Uncharacterized protein F44E2.2, putative |
Schistosoma japonicum | Sjp_0034220 | Retrovirus-related Pol polyprotein from transposon 17.6 [Includes: Protease, putative |
Schistosoma japonicum | Sjp_0066450 | Conserved hypothetical protein |
Schistosoma japonicum | Sjp_0095510 | Retrovirus-related Pol polyprotein from transposon 17.6 [Includes: Protease, putative |
Schistosoma japonicum | Sjp_0028150 | Retrovirus-related Pol polyprotein from transposon 17.6 [Includes: Protease, putative |
Schistosoma japonicum | Sjp_0219410 | Retrovirus-related Pol polyprotein from transposon 17.6 [Includes: Protease, putative |
Schistosoma japonicum | Sjp_0219330 | IPR001584,Integrase, catalytic region,domain-containing |
Schistosoma japonicum | Sjp_0044570 | Conserved hypothetical protein |
Schistosoma japonicum | Sjp_0088880 | similar to Uncharacterized protein F44E2.2, putative |
Schistosoma japonicum | Sjp_0116760 | Conserved hypothetical protein |
Schistosoma japonicum | Sjp_0056250 | IPR001584,Integrase, catalytic region;IPR012337,Polynucleotidyl transferase, Ribonuclease H fold,domain-containing |
Schistosoma japonicum | Sjp_0117980 | Retrovirus-related Pol polyprotein from transposon 17.6 [Includes: Protease, putative |
Schistosoma japonicum | Sjp_0102730 | similar to Uncharacterized protein F44E2.2, putative |
Schistosoma japonicum | Sjp_0105820 | IPR001584,Integrase, catalytic region;IPR012337,Polynucleotidyl transferase, Ribonuclease H fold,domain-containing |
Schistosoma japonicum | Sjp_0113030 | similar to Uncharacterized protein F44E2.2, putative |
Schistosoma japonicum | Sjp_0308780 | IPR012337,Polynucleotidyl transferase, Ribonuclease H fold;IPR001584,Integrase, catalytic core,domain-containing |
Schistosoma japonicum | Sjp_0005040 | IPR012337,Polynucleotidyl transferase, Ribonuclease H fold,domain-containing |
Schistosoma japonicum | Sjp_0087230 | similar to Uncharacterized protein F44E2.2, putative |
Schistosoma japonicum | Sjp_0099320 | similar to Retrotransposable element Tf2 155 kDa protein type 2, putative |
Schistosoma japonicum | Sjp_0065290 | Retrovirus-related Pol polyprotein from transposon 17.6 [Includes: Protease, putative |
Schistosoma japonicum | Sjp_0112640 | similar to Uncharacterized protein F44E2.2, putative |
Schistosoma japonicum | Sjp_0083180 | Transposon Ty3-I Gag-Pol polyprotein, putative |
Schistosoma japonicum | Sjp_0071250 | Retrovirus-related Pol polyprotein from transposon 17.6 [Includes: Protease, putative |
Schistosoma japonicum | Sjp_0112290 | similar to Uncharacterized protein F44E2.2, putative |
Schistosoma japonicum | Sjp_0121280 | IPR000477,RNA-directed DNA polymerase (Reverse transcriptase),domain-containing |
Schistosoma japonicum | Sjp_0125250 | similar to Uncharacterized protein F44E2.2, putative |
Schistosoma japonicum | Sjp_0019980 | IPR001584,Integrase, catalytic region;IPR012337,Polynucleotidyl transferase, Ribonuclease H fold,domain-containing |
Schistosoma japonicum | Sjp_0102620 | Retrovirus-related Pol polyprotein from transposon 17.6 [Includes: Protease, putative |
Schistosoma japonicum | Sjp_0128310 | Retrovirus-related Pol polyprotein from transposon 17.6 [Includes: Protease, putative |
Schistosoma japonicum | Sjp_0120660 | IPR001584,Integrase, catalytic region;IPR012337,Polynucleotidyl transferase, Ribonuclease H fold,domain-containing |
Schistosoma japonicum | Sjp_0118760 | Retrovirus-related Pol polyprotein from transposon 17.6 [Includes: Protease, putative |
Schistosoma japonicum | Sjp_0208350 | Transposon Ty3-G Gag-Pol polyprotein, putative |
Schistosoma japonicum | Sjp_0059110 | Conserved hypothetical protein |
Schistosoma japonicum | Sjp_0125080 | Transposon Ty3-I Gag-Pol polyprotein, putative |
Schistosoma japonicum | Sjp_0219690 | Retrovirus-related Pol polyprotein from transposon 17.6 [Includes: Protease, putative |
Schistosoma japonicum | Sjp_0112630 | similar to Uncharacterized protein F44E2.2, putative |
Schistosoma japonicum | Sjp_0122430 | Retrovirus-related Pol polyprotein from transposon 17.6 [Includes: Protease, putative |
Schistosoma japonicum | Sjp_0126520 | Retrovirus-related Pol polyprotein from transposon 17.6 [Includes: Protease, putative |
Schistosoma japonicum | Sjp_0124770 | Retrovirus-related Pol polyprotein from transposon 412 [Includes: Protease, putative |
Schistosoma japonicum | Sjp_0013710 | similar to Uncharacterized protein F44E2.2, putative |
Schistosoma japonicum | Sjp_0080080 | Retrovirus-related Pol polyprotein from transposon 17.6 [Includes: Protease, putative |
Schistosoma japonicum | Sjp_0120220 | similar to Retrotransposable element Tf2 155 kDa protein type 2, putative |
Schistosoma japonicum | Sjp_0079340 | Retrovirus-related Pol polyprotein from transposon 412 [Includes: Protease, putative |
Schistosoma japonicum | Sjp_0092130 | Retrovirus-related Pol polyprotein from transposon 17.6 [Includes: Protease, putative |
Schistosoma japonicum | Sjp_0132220 | Retrovirus-related Pol polyprotein from transposon 17.6 [Includes: Protease, putative |
Schistosoma japonicum | Sjp_0001020 | Retrovirus-related Pol polyprotein from transposon 297 [Includes: Protease, putative |
Schistosoma japonicum | Sjp_0091430 | Retrovirus-related Pol polyprotein from transposon 17.6 [Includes: Protease, putative |
Schistosoma japonicum | Sjp_0062130 | Retrovirus-related Pol polyprotein from transposon 17.6 [Includes: Protease, putative |
Schistosoma japonicum | Sjp_0117280 | similar to Uncharacterized protein F44E2.2, putative |
Schistosoma japonicum | Sjp_0109720 | similar to Uncharacterized protein F44E2.2, putative |
Schistosoma japonicum | Sjp_0051370 | Retrovirus-related Pol polyprotein from transposon 17.6 [Includes: Protease, putative |
Schistosoma japonicum | Sjp_0105160 | Retrovirus-related Pol polyprotein from transposon 17.6 [Includes: Protease, putative |
Schistosoma japonicum | Sjp_0126620 | similar to Uncharacterized protein F44E2.2, putative |
Schistosoma japonicum | Sjp_0009480 | Retrovirus-related Pol polyprotein from transposon 17.6 [Includes: Protease, putative |
Schistosoma japonicum | Sjp_0093220 | hypothetical protein |
Schistosoma japonicum | Sjp_0044240 | Retrovirus-related Pol polyprotein from transposon 17.6 [Includes: Protease, putative |
Schistosoma japonicum | Sjp_0029130 | hypothetical protein |
Schistosoma japonicum | Sjp_0069240 | IPR001995,Peptidase A2A, retrovirus, catalytic;IPR001969,Peptidase aspartic, active site;IPR009007,Peptidase aspartic, catalytic |
Schistosoma japonicum | Sjp_0097440 | similar to Uncharacterized protein F44E2.2, putative |
Schistosoma japonicum | Sjp_0109440 | similar to Uncharacterized protein F44E2.2, putative |
Schistosoma japonicum | Sjp_0064230 | Conserved hypothetical protein |
Schistosoma japonicum | Sjp_0112140 | Retrovirus-related Pol polyprotein from transposon 17.6 [Includes: Protease, putative |
Schistosoma japonicum | Sjp_0064830 | Transposon Ty3-I Gag-Pol polyprotein, putative |
Schistosoma japonicum | Sjp_0035250 | Conserved hypothetical protein |
Schistosoma japonicum | Sjp_0062150 | similar to Uncharacterized protein F44E2.2, putative |
Schistosoma japonicum | Sjp_0118740 | Retrovirus-related Pol polyprotein from transposon 17.6 [Includes: Protease, putative |
Schistosoma japonicum | Sjp_0012080 | similar to Uncharacterized protein F44E2.2, putative |
Schistosoma japonicum | Sjp_0119800 | similar to Uncharacterized protein F44E2.2, putative |
Schistosoma japonicum | Sjp_0112040 | Retrovirus-related Pol polyprotein from transposon 17.6 [Includes: Protease, putative |
Schistosoma japonicum | Sjp_0123880 | similar to Uncharacterized protein F44E2.2, putative |
Schistosoma mansoni | Smp_168700 | hypothetical protein |
Schmidtea mediterranea | mk4.019373.00 | |
Schmidtea mediterranea | mk4.031486.00 | |
Schmidtea mediterranea | mk4.029692.00 | |
Schmidtea mediterranea | mk4.000995.01 | |
Schmidtea mediterranea | mk4.015913.02 | |
Schmidtea mediterranea | mk4.002198.04 | |
Schmidtea mediterranea | mk4.027279.00 | |
Schmidtea mediterranea | mk4.002407.01 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Species | Target | Length | Identity | Alignment span | Linked Drugs | Reference |
---|---|---|---|---|---|---|
Woolly monkey sarcoma virus | Simian sarcoma virus Pol protein | 294 aa | 28.9% | 277 aa | Compounds | References |