Detailed view for Sjp_0074710

Basic information

TDR Targets ID: 974996
Schistosoma japonicum, ko:K08839 serine/threonine kinase 25, putative
Source Database / ID:  Wormbase Parasite  

pI: 6.7827 | Length (AA): 683 | MW (Da): 74826 | Paralog Number: 0

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0

Druggability Group : DG

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00069   Protein kinase domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0005524   ATP binding  
GO:0004672   protein kinase activity  
GO:0006468   protein amino acid phosphorylation  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 4 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
11 333 3a7i (A) 16 299 69.00 0 1 1.13681 -0.49
14 332 3ggf (A) 19 298 71.00 0 1 1.09194 -0.09
14 331 3ggf (B) 19 297 57.00 0 1 0.846576 0.02
17 425 3mwu (A) 74 440 26.00 0 1 0.659907 0.54

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_127277)

Species Accession Gene Product
Arabidopsis thaliana AT1G53165   map 4 kinase alpha1
Arabidopsis thaliana AT3G15220   putative protein kinase
Candida albicans CaO19.7821   Serine/threonine protein kinase
Candida albicans CaO19.191   Serine/threonine protein kinase
Caenorhabditis elegans CELE_T19A5.2   Protein GCK-1, isoform A
Dictyostelium discoideum DDB_G0286359   STE20 family protein kinase
Dictyostelium discoideum DDB_G0267978   MST subfamily kinase
Drosophila melanogaster Dmel_CG5169   Germinal centre kinase III
Echinococcus granulosus EgrG_000423200   serine threonine protein kinase
Entamoeba histolytica EHI_023610   protein kinase, putative
Echinococcus multilocularis EmuJ_000423200   serine threonine protein kinase
Homo sapiens ENSG00000102572   serine/threonine kinase 24
Homo sapiens ENSG00000134602   serine/threonine protein kinase 26
Homo sapiens ENSG00000115694   serine/threonine kinase 25
Loa Loa (eye worm) LOAG_11902   STE/STE20/YSK protein kinase
Mus musculus 70415   serine/threonine kinase 26
Mus musculus ENSMUSG00000063410   serine/threonine kinase 24
Mus musculus 59041   serine/threonine kinase 25 (yeast)
Oryza sativa 4343333   Os07g0507300
Plasmodium falciparum PF3D7_0203100   protein kinase, putative
Plasmodium vivax PVX_003590   serine/threonine-specific protein kinase, putative
Saccharomyces cerevisiae YDR523C   Sps1p
Saccharomyces cerevisiae YHR102W   Kic1p
Schistosoma japonicum Sjp_0074710   ko:K08839 serine/threonine kinase 25, putative
Schistosoma mansoni Smp_096640   serine/threonine protein kinase
Schmidtea mediterranea mk4.001445.05  
Schmidtea mediterranea mk4.002264.12  
Schmidtea mediterranea mk4.007384.01   Mitogen-activated protein kinase kinase kinase 8
Schmidtea mediterranea mk4.001739.09  
Trichomonas vaginalis TVAG_337440   STE family protein kinase
Trichomonas vaginalis TVAG_004100   STE family protein kinase

Essentiality

Sjp_0074710 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_T19A5.2 Caenorhabditis elegans sterile wormbase
Show/Hide essentiality data references
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens serine/threonine kinase 25 Compounds References
Homo sapiens serine/threonine protein kinase 26 Compounds References
Homo sapiens serine/threonine kinase 24 Compounds References
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Homo sapiens Cyclin-dependent kinase 1/cyclin B1 297 aa 30.1% 239 aa Compounds References
Rattus norvegicus MAP kinase p38 alpha 360 aa 23.3% 331 aa Compounds References
Oryctolagus cuniculus Cyclin-dependent kinase 4 189 aa 27.6% 152 aa Compounds References
Rattus norvegicus Jak1 protein 210 aa 25.1% 239 aa Compounds References
Bos taurus cAMP-dependent protein kinase alpha-catalytic subunit 351 aa 27.9% 283 aa Compounds References
Rattus norvegicus cAMP-dependent protein kinase alpha-catalytic subunit 351 aa 26.7% 281 aa Compounds References
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Sjp_0074710 (Schistosoma japonicum), ko:K08839 serine/threonine kinase 25, putative
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