Detailed view for Sjp_0211540

Basic information

TDR Targets ID: 975380
Schistosoma japonicum, ko:K04145 dopamine receptor D2, putative
Source Database / ID:  Wormbase Parasite  

pI: 9.0097 | Length (AA): 682 | MW (Da): 77388 | Paralog Number: 0

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 7

Druggability Group : DG

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00001   7 transmembrane receptor (rhodopsin family)

Gene Ontology

Mouse over links to read term descriptions.
GO:0016021   integral to membrane  
GO:0004930   G-protein coupled receptor activity  
GO:0007186   G-protein coupled receptor protein signaling pathway  

Structural information

Modbase 3D models:

No model available for this protein in Modbase.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_137854)

Species Accession Gene Product
Brugia malayi Bm1_52070   Dopamine receptor protein 2
Caenorhabditis elegans CELE_T14E8.3   Protein DOP-3, isoform A
Caenorhabditis elegans CELE_K09G1.4   Protein DOP-2, isoform C
Drosophila melanogaster Dmel_CG33517   Dopamine 2-like receptor
Loa Loa (eye worm) LOAG_01974   hypothetical protein
Loa Loa (eye worm) LOAG_01975   hypothetical protein
Onchocerca volvulus OVOC6740  
Schistosoma japonicum Sjp_0211540   ko:K04145 dopamine receptor D2, putative
Schistosoma mansoni Smp_127310   biogenic amine (dopamine) receptor
Schmidtea mediterranea mk4.023028.00  
Schmidtea mediterranea mk4.021073.00  
Schmidtea mediterranea mk4.002521.01  
Schmidtea mediterranea mk4.012183.03  
Schmidtea mediterranea mk4.027599.00   Putative g-protein coupled receptor
Schmidtea mediterranea mk4.017367.00   Putative alpha-1 adrenergic receptor
Schmidtea mediterranea mk4.010946.00  
Schmidtea mediterranea mk4.019924.00  
Schmidtea mediterranea mk4.002521.02   Putative g-protein coupled receptor
Schmidtea mediterranea mk4.041158.00  
Schmidtea mediterranea mk4.019345.00   Putative alpha-1 adrenergic receptor
Schmidtea mediterranea mk4.002267.00  
Schmidtea mediterranea mk4.012395.01  
Schmidtea mediterranea mk4.033627.00   Putative alpha-1 adrenergic receptor
Schmidtea mediterranea mk4.027215.00   Biogenic amine

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Bos taurus 5-hydroxytryptamine 1D receptor 119 aa 36.8% 117 aa Compounds References
Macaca mulatta Gonadotropin-releasing hormone receptor 59 aa 23.3% 60 aa Compounds References
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Sjp_0211540 (Schistosoma japonicum), ko:K04145 dopamine receptor D2, putative
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