Detailed view for Sjp_0217440

Basic information

TDR Targets ID: 975518
Schistosoma japonicum, ko:K01415 endothelin-converting enzyme [EC3.4.24.71], putative
Source Database / ID:  Wormbase Parasite  

pI: 5.933 | Length (AA): 805 | MW (Da): 92901 | Paralog Number: 1

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 1

Druggability Group : DG

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF01431   Peptidase family M13
PF05649   Peptidase family M13

Gene Ontology

Mouse over links to read term descriptions.
GO:0008237   metallopeptidase activity  
GO:0004222   metalloendopeptidase activity  
GO:0006508   proteolysis  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

No model available for this protein in Modbase.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_127344)

Species Accession Gene Product
Brugia malayi Bm1_43745   Peptidase family M13 containing protein
Brugia malayi Bm1_50770   Hypothetical zinc metalloproteinase T16A9.4
Caenorhabditis elegans CELE_F18A12.8   Protein NEP-11, isoform A
Caenorhabditis elegans CELE_T05A8.4   Protein NEP-2
Caenorhabditis elegans CELE_T16A9.4   Protein NEP-21, isoform A
Drosophila melanogaster Dmel_CG4058   Neprilysin 4
Drosophila melanogaster Dmel_CG5905   Neprilysin 1
Drosophila melanogaster Dmel_CG9565   Neprilysin 3
Echinococcus granulosus EgrG_001177500   endothelin converting enzyme 1
Echinococcus multilocularis EmuJ_001177500   endothelin converting enzyme 1
Homo sapiens ENSG00000142606   membrane metallo-endopeptidase-like 1
Homo sapiens ENSG00000117298   endothelin converting enzyme 1
Homo sapiens ENSG00000145194   endothelin converting enzyme 2
Homo sapiens ENSG00000196549   membrane metallo-endopeptidase
Loa Loa (eye worm) LOAG_14244   hypothetical protein
Loa Loa (eye worm) LOAG_10000   hypothetical protein
Loa Loa (eye worm) LOAG_01595   hypothetical protein
Loa Loa (eye worm) LOAG_15321   hypothetical protein
Loa Loa (eye worm) LOAG_12742   hypothetical protein
Loa Loa (eye worm) LOAG_15702   hypothetical protein
Loa Loa (eye worm) LOAG_15151   peptidase family M13 containing protein
Loa Loa (eye worm) LOAG_14395   peptidase family M13 containing protein
Loa Loa (eye worm) LOAG_14655   hypothetical protein
Loa Loa (eye worm) LOAG_15429   hypothetical protein
Loa Loa (eye worm) LOAG_12845   hypothetical protein
Loa Loa (eye worm) LOAG_14818   hypothetical protein
Loa Loa (eye worm) LOAG_15355   hypothetical protein
Loa Loa (eye worm) LOAG_14969   hypothetical protein
Loa Loa (eye worm) LOAG_14910   hypothetical protein
Loa Loa (eye worm) LOAG_00293   hypothetical protein
Mycobacterium leprae ML2613c   probable zinc metalloprotease
Mus musculus 17380   membrane metallo endopeptidase
Mus musculus ENSMUSG00000058183   membrane metallo-endopeptidase-like 1
Mus musculus ENSMUSG00000057530   endothelin converting enzyme 1
Mycobacterium tuberculosis Rv0198c   Probable zinc metalloprotease Zmp1
Mycobacterium ulcerans MUL_1088   zinc metalloprotease
Neospora caninum NCLIV_002180   hypothetical protein
Onchocerca volvulus OVOC12619  
Schistosoma japonicum Sjp_0217440   ko:K01415 endothelin-converting enzyme [EC3.4.24.71], putative
Schistosoma japonicum Sjp_0115870   IPR000718,Peptidase M13, neprilysin,domain-containing
Schistosoma mansoni Smp_159370   family M13 unassigned peptidase (M13 family)
Schmidtea mediterranea mk4.004213.03   AT14086p
Schmidtea mediterranea mk4.005225.04   AT14086p
Schmidtea mediterranea mk4.065770.00   AT14086p
Schmidtea mediterranea mk4.000478.03  
Schmidtea mediterranea mk4.005782.00   AT14086p
Schmidtea mediterranea mk4.005225.01  
Schmidtea mediterranea mk4.001108.04   AT14086p
Schmidtea mediterranea mk4.005225.02   AT14086p
Schmidtea mediterranea mk4.013196.02  
Schmidtea mediterranea mk4.040373.01  
Schmidtea mediterranea mk4.013196.04   Kell blood group glycoprotein
Schmidtea mediterranea mk4.013196.00  
Toxoplasma gondii TGME49_295640   peptidase family M13 protein

Essentiality

Sjp_0217440 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
TGME49_295640 Toxoplasma gondii Probably non-essential sidik
Show/Hide essentiality data references
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens membrane metallo-endopeptidase Compounds References
Rattus norvegicus Neprilysin Compounds References
Sus scrofa Neprilysin Compounds References
Homo sapiens endothelin converting enzyme 2 Compounds References
Rattus norvegicus Endothelin-converting enzyme 1 Compounds References
Mus musculus membrane metallo endopeptidase Compounds References
Homo sapiens membrane metallo-endopeptidase-like 1 Compounds References
Oryctolagus cuniculus Neprilysin Compounds References
Bos taurus Endothelin-converting enzyme 1 Compounds References
Homo sapiens endothelin converting enzyme 1 Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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Gene identifier Sjp_0217440 (Schistosoma japonicum), ko:K01415 endothelin-converting enzyme [EC3.4.24.71], putative
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