Detailed view for Sjp_0029310

Basic information

TDR Targets ID: 975714
Schistosoma japonicum, Calpain-9, putative
Source Database / ID:  Wormbase Parasite  

pI: 7.3574 | Length (AA): 791 | MW (Da): 88938 | Paralog Number: 0

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0

Druggability Group : DG

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00648   Calpain family cysteine protease
PF01067   Calpain large subunit, domain III

Gene Ontology

Mouse over links to read term descriptions.
GO:0005622   intracellular  
GO:0004198   calcium-dependent cysteine-type endopeptidase activity  
GO:0006508   proteolysis  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 4 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
85 790 1df0 (A) 7 665 33.00 0 1 0.998971 0.89
107 761 3bow (A) 29 634 36.00 0 1 1.15471 0.18
658 790 4okh (A) 651 785 24.00 0.67 0.99 0.544654 -1.03
675 738 2i7a (A) 516 577 46.00 0.00011 1 0.621613 -1.07

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_246060)

Species Accession Gene Product
Echinococcus granulosus EgrG_000253150   calpain A
Echinococcus multilocularis EmuJ_000253150   hypothetical protein
Schistosoma japonicum Sjp_0029310   Calpain-9, putative
Schistosoma mansoni Smp_137410   calpain C (C02 family)
Schmidtea mediterranea mk4.008380.00  

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Gallus gallus Calpain 1/2 705 aa 33.1% 667 aa Compounds References
Sus scrofa Calpain 2 324 aa 27.6% 275 aa Compounds References
Sus scrofa Calpain 1 714 aa 33.8% 671 aa Compounds References
Bos taurus Calpain 2 700 aa 32.6% 663 aa Compounds References
Rattus norvegicus Calpain 1 713 aa 33.8% 669 aa Compounds References
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Sjp_0029310 (Schistosoma japonicum), Calpain-9, putative
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