Detailed view for Sjp_0070510

Basic information

TDR Targets ID: 976202
Schistosoma japonicum, Acetylcholinesterase 1 precursor, putative
Source Database / ID:  Wormbase Parasite  

pI: 6.5003 | Length (AA): 453 | MW (Da): 51938 | Paralog Number: 1

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0

Druggability Group : DG

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00135   Carboxylesterase family

Gene Ontology

Mouse over links to read term descriptions.
GO:0004104   cholinesterase activity  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 3 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
26 368 6emi (A) 234 522 35.00 0 1 0.85395 0.97
188 390 4bdt (A) 365 551 30.00 0 1 0.747515 0
252 368 4qww (A) 421 524 39.00 0 0.99 0.52625 0.36

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_126875)

Species Accession Gene Product
Brugia malayi Bm1_47660   Carboxylesterase family protein
Brugia malayi Bm1_46735   Carboxylesterase family protein
Caenorhabditis elegans CELE_Y44E3A.2   Protein ACE-2
Caenorhabditis elegans CELE_W09B12.1   Protein ACE-1
Dictyostelium discoideum DDB_G0283087   carboxylesterase, type B family protein
Dictyostelium discoideum DDB_G0291344   carboxylesterase, type B family protein
Dictyostelium discoideum DDB_G0279717   carboxylesterase, type B family protein
Drosophila melanogaster Dmel_CG17907   Acetylcholine esterase
Echinococcus granulosus EgrG_000732400   acetylcholinesterase
Echinococcus granulosus EgrG_000783300   carboxylesterase 5A
Echinococcus granulosus EgrG_001075400   acetylcholinesterase
Echinococcus multilocularis EmuJ_000783300   carboxylesterase 5A
Echinococcus multilocularis EmuJ_001075400   acetylcholinesterase
Echinococcus multilocularis EmuJ_000732400   acetylcholinesterase
Homo sapiens ENSG00000087085   acetylcholinesterase (Yt blood group)
Homo sapiens ENSG00000114200   butyrylcholinesterase
Loa Loa (eye worm) LOAG_03918   acetylcholinesterase 1
Loa Loa (eye worm) LOAG_09411   hypothetical protein
Loa Loa (eye worm) LOAG_05902   hypothetical protein
Loa Loa (eye worm) LOAG_11325   carboxylesterase
Mus musculus ENSMUSG00000023328   acetylcholinesterase
Mus musculus ENSMUSG00000027792   butyrylcholinesterase
Schistosoma japonicum Sjp_0045440   ko:K01049 acetylcholinesterase [EC3.1.1.7], putative
Schistosoma japonicum Sjp_0070510   Acetylcholinesterase 1 precursor, putative
Schistosoma mansoni Smp_136690   family S9 non-peptidase homologue (S09 family)
Schmidtea mediterranea mk4.000742.13   Acetylcholinesterase 1
Schmidtea mediterranea mk4.026083.02   BC026374 protein
Schmidtea mediterranea mk4.020267.02   BC026374 protein
Schmidtea mediterranea mk4.000091.05   Acetylcholine esterase
Schmidtea mediterranea mk4.000742.14  

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Musca domestica Acetylcholinesterase Compounds References
Homo sapiens acetylcholinesterase (Yt blood group) Compounds References
Bos taurus Acetylcholinesterase Compounds References
Torpedo californica Acetylcholinesterase Compounds References
Mus musculus butyrylcholinesterase Compounds References
Mus musculus acetylcholinesterase Compounds References
Equus caballus Cholinesterase Compounds References
Rattus norvegicus Acetylcholinesterase Compounds References
Equus caballus Butyrylcholinesterase Compounds References
Drosophila melanogaster Acetylcholine esterase Compounds References
Gallus gallus Acetylcholinesterase Compounds References
Electrophorus electricus Acetylcholinesterase Compounds References
Homo sapiens butyrylcholinesterase Compounds References
Rattus norvegicus Butyrylcholinesterase Compounds References
Laodelphax striatella Acetylcholinesterase Compounds References
Anopheles gambiae Acetylcholinesterase Compounds References
Nephotettix cincticeps Ace-orthologous acetylcholinesterase Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Sjp_0070510 (Schistosoma japonicum), Acetylcholinesterase 1 precursor, putative
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