Detailed view for Sjp_0022650

Basic information

TDR Targets ID: 976562
Schistosoma japonicum, ko:K08027 nuclear receptor, subfamily 5, group A, member 2, putative
Source Database / ID:  Wormbase Parasite  

pI: 5.3789 | Length (AA): 957 | MW (Da): 101890 | Paralog Number: 0

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0

Druggability Group : DG

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00104   Ligand-binding domain of nuclear hormone receptor
PF00105   Zinc finger, C4 type (two domains)

Gene Ontology

Mouse over links to read term descriptions.
GO:0006355   regulation of transcription, DNA-dependent  
GO:0005634   nucleus  
GO:0003707   steroid hormone receptor activity  
GO:0003700   transcription factor activity  
GO:0003677   DNA binding  
GO:0043565   sequence-specific DNA binding  
GO:0008270   zinc ion binding  

Metabolic Pathways

Maturity onset diabetes of the young (KEGG)

Structural information

Modbase 3D models:

There are 4 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
378 451 1r4i (A) 541 611 48.00 0 1 0.643806 -0.52
379 472 2ff0 (A) 13 107 62.00 0 1 0.800326 -0.62
379 852 3dzy (A) 135 455 37.00 0 1 0.195816 1.7
638 852 4n1y (A) 255 470 20.00 0.00000012 1 0.659895 -1.45

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_131813)

Species Accession Gene Product
Brugia malayi Bm1_14755   Nuclear hormone receptor family member nhr-25
Brugia malayi Bm1_33595   Nuclear hormone receptor family member nhr-25
Caenorhabditis elegans CELE_F11C1.6   Protein NHR-25, isoform A
Drosophila melanogaster Dmel_CG4059   ftz transcription factor 1
Echinococcus granulosus EgrG_000814300   FTZ F1 nuclear receptor protein
Echinococcus multilocularis EmuJ_000814300   FTZ F1 nuclear receptor protein
Echinococcus multilocularis EmuJ_000763500   FTZ F1 alpha
Homo sapiens ENSG00000116833   nuclear receptor subfamily 5, group A, member 2
Loa Loa (eye worm) LOAG_02263   hypothetical protein
Mus musculus ENSMUSG00000026398   nuclear receptor subfamily 5, group A, member 2
Schistosoma japonicum Sjp_0022650   ko:K08027 nuclear receptor, subfamily 5, group A, member 2, putative
Schistosoma mansoni Smp_068780   FTZ-F1 nuclear receptor-like protein
Schistosoma mansoni Smp_106230   hypothetical protein
Schmidtea mediterranea mk4.000915.03   Nuclear hormone receptor family member nhr-25

Essentiality

Sjp_0022650 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_F11C1.6 Caenorhabditis elegans embryonic lethal wormbase
CELE_F11C1.6 Caenorhabditis elegans larval lethal wormbase
CELE_F11C1.6 Caenorhabditis elegans slow growth wormbase
CELE_F11C1.6 Caenorhabditis elegans sterile wormbase
Show/Hide essentiality data references
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens nuclear receptor subfamily 5, group A, member 2 Compounds References
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Heliothis virescens Ecdysone receptor 264 aa 26.9% 212 aa Compounds References
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Sjp_0022650 (Schistosoma japonicum), ko:K08027 nuclear receptor, subfamily 5, group A, member 2, putative
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