Detailed view for Sjp_0106630

Basic information

TDR Targets ID: 976736
Schistosoma japonicum, ko:K08826 homeodomain interacting protein kinase, putative
Source Database / ID:  Wormbase Parasite  

pI: 7.9037 | Length (AA): 749 | MW (Da): 84190 | Paralog Number: 1

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0

Druggability Group : DG

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00069   Protein kinase domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0005524   ATP binding  
GO:0004672   protein kinase activity  
GO:0006468   protein amino acid phosphorylation  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 6 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
125 502 5y86 (A) 161 525 35.00 0 1 0.918248 -0.58
125 499 3kvw (A) 101 462 39.00 0 1 0.917737 -0.29
136 525 5ci6 (A) 32 378 28.00 0 1 0.55729 0.59
148 500 5a4e (B) 137 480 42.00 0 1 0.890825 -0.44
167 554 1kob (A) 47 367 22.00 0 1 0.507617 0.56
199 464 1q8y (B) 184 700 32.00 0 1 0.761015 -0.78

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_129272)

Species Accession Gene Product
Brugia malayi Bm1_21245   Homeodomain interacting protein kinase protein 1
Candida albicans CaO19.147   similar to C terminus of S. cerevisiae YAK1 (YJL141C) serine-threonine protein kinase
Candida albicans CaO19.148   hypothetical protein
Candida albicans CaO19.7787   similar to C terminus of S. cerevisiae YAK1 (YJL141C) serine-threonine protein kinase
Candida albicans CaO19.7788   hypothetical protein
Caenorhabditis elegans CELE_F20B6.8   Protein HPK-1, isoform C
Drosophila melanogaster Dmel_CG17090   homeodomain interacting protein kinase
Echinococcus granulosus EgrG_001067800   homeodomain interacting protein kinase 3
Entamoeba histolytica EHI_153120   protein kinase domain containing protein
Echinococcus multilocularis EmuJ_001067800   homeodomain interacting protein kinase 3
Homo sapiens ENSG00000163349   homeodomain interacting protein kinase 1
Homo sapiens ENSG00000064393   homeodomain interacting protein kinase 2
Homo sapiens ENSG00000110422   homeodomain interacting protein kinase 3
Loa Loa (eye worm) LOAG_04459   CMGC/DYRK/HIPK protein kinase
Mus musculus ENSMUSG00000027177   homeodomain interacting protein kinase 3
Mus musculus ENSMUSG00000061436   homeodomain interacting protein kinase 2
Mus musculus ensembl-mmu:ENSMUSG00000008730   homeodomain interacting protein kinase 1
Schistosoma japonicum Sjp_0106630   ko:K08826 homeodomain interacting protein kinase, putative
Schistosoma japonicum Sjp_0013650   expressed protein
Schistosoma mansoni Smp_000720   serine/threonine protein kinase
Schmidtea mediterranea mk4.001360.04   Homeodomain-interacting protein kinase 4

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens homeodomain interacting protein kinase 3 Compounds References
Homo sapiens homeodomain interacting protein kinase 1 Compounds References
Homo sapiens homeodomain interacting protein kinase 2 Compounds References
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Homo sapiens Cyclin-dependent kinase 1/cyclin B1 297 aa 28.2% 238 aa Compounds References
Rattus norvegicus Cell division protein kinase 5 292 aa 32.5% 243 aa Compounds References
Rattus norvegicus Mitogen-activated protein kinase 8 411 aa 25.6% 351 aa Compounds References
Oryctolagus cuniculus Cyclin-dependent kinase 4 189 aa 35.3% 173 aa Compounds References
Schizosaccharomyces pombe 972h- Casein kinase II subunit alpha 332 aa 25.4% 338 aa Compounds References
Zea mays Casein kinase II alpha 332 aa 23.4% 337 aa Compounds References
Plasmodium falciparum (isolate 3D7) Cell division control protein 2 homolog 288 aa 28.3% 343 aa Compounds References
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Sjp_0106630 (Schistosoma japonicum), ko:K08826 homeodomain interacting protein kinase, putative
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