Detailed view for Sjp_0067850

Basic information

TDR Targets ID: 976867
Schistosoma japonicum, ko:K00871 phosphorylase kinase gamma subunit [EC2.7.11.19], putative
Source Database / ID:  Wormbase Parasite  

pI: 4.7655 | Length (AA): 259 | MW (Da): 28960 | Paralog Number: 1

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0

Druggability Group : DG

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00069   Protein kinase domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0005524   ATP binding  
GO:0004672   protein kinase activity  
GO:0006468   protein amino acid phosphorylation  

Structural information

Modbase 3D models:

There are 4 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
4 251 4oli (A) 835 1088 29.00 0 1 1.00803 1.22
42 251 2y7j (A) 11 220 48.00 0 1 1.40131 -0.48
51 251 1phk (A) 15 216 50.00 0 1 1.35636 -0.49
177 209 5b2m (A) 255 303 55.00 0.062 0.14 0.462713 1.6

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_131741)

Species Accession Gene Product
Brugia malayi Bm1_44555   Protein kinase domain containing protein
Caenorhabditis elegans CELE_Y50D7A.3   Protein Y50D7A.3, isoform B
Drosophila melanogaster Dmel_CG1830   Phosphorylase kinase gamma
Echinococcus granulosus EgrG_001095600   phosphorylase kinase gamma subunit
Echinococcus multilocularis EmuJ_001095600   phosphorylase kinase gamma subunit
Homo sapiens ENSG00000156873   phosphorylase kinase, gamma 2 (testis)
Homo sapiens ENSG00000164776   phosphorylase kinase, gamma 1 (muscle)
Loa Loa (eye worm) LOAG_07421   CAMK/PHK protein kinase
Mus musculus ENSMUSG00000025537   phosphorylase kinase gamma 1
Mus musculus ENSMUSG00000030815   phosphorylase kinase, gamma 2 (testis)
Onchocerca volvulus OVOC8295   Serine\/threonine kinase homolog
Schistosoma japonicum Sjp_0067850   ko:K00871 phosphorylase kinase gamma subunit [EC2.7.11.19], putative
Schistosoma japonicum Sjp_0050020   Conserved hypothetical protein
Schistosoma mansoni Smp_098840   serine/threonine protein kinase
Schmidtea mediterranea mk4.031012.00   GH28523p
Schmidtea mediterranea mk4.005224.02   GH28523p
Schmidtea mediterranea mk4.021320.00   GH28523p
Schmidtea mediterranea mk4.022188.00   GH28523p
Schmidtea mediterranea mk4.002161.05   Serine/threonine kinase
Schmidtea mediterranea mk4.026067.00   GH28523p

Essentiality

Sjp_0067850 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_Y50D7A.3 Caenorhabditis elegans slow growth wormbase
CELE_Y50D7A.3 Caenorhabditis elegans sterile wormbase
Show/Hide essentiality data references
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens phosphorylase kinase, gamma 2 (testis) Compounds References
Homo sapiens phosphorylase kinase, gamma 1 (muscle) Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Sjp_0067850 (Schistosoma japonicum), ko:K00871 phosphorylase kinase gamma subunit [EC2.7.11.19], putative
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