Detailed view for Sjp_0023430

Basic information

TDR Targets ID: 977073
Schistosoma japonicum, ko:K04674 transforming growth factor, beta receptor I, putative
Source Database / ID:  Wormbase Parasite  

pI: 6.7269 | Length (AA): 769 | MW (Da): 85240 | Paralog Number: 0

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 1

Druggability Group : DG

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00069   Protein kinase domain
PF08515   Transforming growth factor beta type I GS-motif

Gene Ontology

Mouse over links to read term descriptions.
GO:0016020   membrane  
GO:0005524   ATP binding  
GO:0004675   transmembrane receptor protein serine/threonine kinase activity  
GO:0004672   protein kinase activity  
GO:0007178   transmembrane receptor protein serine/threonine kinase signaling pathway  
GO:0006468   protein amino acid phosphorylation  

Structural information

Modbase 3D models:

There is 1 model calculated for this protein. More info on this model, including the model itself is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
275 602 1b6c (B) 175 498 59.00 0 1 1.16828 -1.08

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_129709)

Species Accession Gene Product
Brugia malayi Bm1_44900   bone morphogenetic protein type 1 receptor
Caenorhabditis elegans CELE_F29C4.1   Protein DAF-1, isoform A
Drosophila melanogaster Dmel_CG8224   baboon
Echinococcus granulosus EgrG_000758400   TGF beta receptor type 1
Echinococcus granulosus EgrG_000195400   TGF-beta receptor type-1
Echinococcus multilocularis EmuJ_000758400   TGF beta receptor type 1
Homo sapiens ENSG00000135503   activin A receptor, type IB
Homo sapiens ENSG00000106799   transforming growth factor, beta receptor 1
Homo sapiens ENSG00000123612   activin A receptor, type IC
Loa Loa (eye worm) LOAG_09357   TKL/STKR/TYPE1 protein kinase
Mus musculus ENSMUSG00000026834   activin A receptor, type IC
Mus musculus ENSMUSG00000007613   transforming growth factor, beta receptor I
Mus musculus ENSMUSG00000000532   activin A receptor, type 1B
Schistosoma japonicum Sjp_0023430   ko:K04674 transforming growth factor, beta receptor I, putative
Schistosoma mansoni Smp_049760   protein kinase
Schmidtea mediterranea mk4.000747.00   Serine/threonine-protein kinase sma-6

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Mus musculus transforming growth factor, beta receptor I Compounds References
Homo sapiens activin A receptor, type IB Compounds References
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Rattus norvegicus Jak1 protein 210 aa 23.4% 235 aa Compounds References
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Sjp_0023430 (Schistosoma japonicum), ko:K04674 transforming growth factor, beta receptor I, putative
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