Detailed view for Sjp_0012740

Basic information

TDR Targets ID: 977321
Schistosoma japonicum, ko:K00736 alpha-1,6-mannosyl-glycoprotein [EC2.4.1.143], putative
Source Database / ID:  Wormbase Parasite  

pI: 9.3601 | Length (AA): 468 | MW (Da): 54528 | Paralog Number: 0

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 1

Druggability Group : DG

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF05060   N-acetylglucosaminyltransferase II (MGAT2)

Gene Ontology

Mouse over links to read term descriptions.
GO:0008455   alpha-1,6-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity  
GO:0016021   integral to membrane  
GO:0005795   Golgi stack  
GO:0009312   oligosaccharide biosynthetic process  

Structural information

Modbase 3D models:

There is 1 model calculated for this protein. More info on this model, including the model itself is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
126 445 5vcm (A) 86 444 39.00 0 1 0.865525 0.01

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_133242)

Species Accession Gene Product
Arabidopsis thaliana AT2G05320   beta-1,2-N-acetylglucosaminyltransferase II
Brugia malayi Bm1_39220   UDP-GlcNAc:a-6-D-mannoside b1,2-N-acetylglucosaminyltransferase II
Caenorhabditis elegans CELE_C03E10.4   Protein GLY-20
Drosophila melanogaster Dmel_CG7921   CG7921 gene product from transcript CG7921-RB
Echinococcus granulosus EgrG_000798500   alpha 16 mannosyl glycoprotein
Echinococcus multilocularis EmuJ_000798500   alpha 1,6 mannosyl glycoprotein
Homo sapiens ENSG00000168282   mannosyl (alpha-1,6-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase
Loa Loa (eye worm) LOAG_02931   hypothetical protein
Mus musculus ENSMUSG00000043998   mannoside acetylglucosaminyltransferase 2
Oryza sativa 4331021   Os02g0798100
Schistosoma japonicum Sjp_0012740   ko:K00736 alpha-1,6-mannosyl-glycoprotein [EC2.4.1.143], putative
Schistosoma mansoni Smp_089240   beta-12-n-acetylglucosaminyltransferase II
Schmidtea mediterranea mk4.022721.00   Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase
Schmidtea mediterranea mk4.021114.00   Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase
Schmidtea mediterranea mk4.033737.00  

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Mus musculus mannoside acetylglucosaminyltransferase 2 Compounds References
Homo sapiens mannosyl (alpha-1,6-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

No user comments are available for this gene. Log in to add comments, or register.

Enter your comment

User ()
Gene identifier Sjp_0012740 (Schistosoma japonicum), ko:K00736 alpha-1,6-mannosyl-glycoprotein [EC2.4.1.143], putative
Title for this comment
Comment