Detailed view for Sjp_0063090

Basic information

TDR Targets ID: 977514
Schistosoma japonicum, ko:K00599 protein arginine N-methyltransferase 5 [EC:2.1.1.-], putative
Source Database / ID:  Wormbase Parasite  

pI: 6.6484 | Length (AA): 1033 | MW (Da): 118792 | Paralog Number: 0

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 1

Druggability Group : DG

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00864   ATP P2X receptor
PF05185   PRMT5 arginine-N-methyltransferase
PF17285   PRMT5 TIM barrel domain
PF17286   PRMT5 oligomerisation domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0098655   GO:cation transmembrane transport  

GO:0035246   peptidyl-arginine N-methylation  
GO:0033198   response to ATP  
GO:0004931   ATP-gated cation channel activity  
GO:0001614   purinergic nucleotide receptor activity  
GO:0005887   integral to plasma membrane  
GO:0008168   methyltransferase activity  
GO:0006479   protein amino acid methylation  

Structural information

Modbase 3D models:

There are 8 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
1 426 5svk (A) 12 355 30.00 0 1 0.14611 2.23
96 408 5u1x (A) 140 349 39.00 0 0.96 0.02413 2.17
496 590 1oqv (A) 64 160 20.00 0 0.89 0.253996 0.38
557 591 3bog (C) 3 73 97.00 0.063 0.9 1.08855 -0.27
567 1092 4g56 (A) 10 586 38.00 0 1 0.726185 0.65
603 1070 4g56 (C) 38 561 44.00 0 1 0.714071 0.63
603 1070 4gqb (A) 43 565 43.00 0 1 0.724071 0.53
802 966 1jsx (A) 1 166 12.00 0 0.22 0.202099 -0.49

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_128174)

Species Accession Gene Product
Arabidopsis thaliana AT4G31120   protein arginine N-methyltransferase 5
Babesia bovis BBOV_IV000750   skb1 methyltransferase family protein, putative
Brugia malayi Bm1_45965   Skb1 methyltransferase family protein
Caenorhabditis elegans CELE_C34E10.5   Protein PRMT-5
Cryptosporidium hominis Chro.70401   protein methyltransferase-related
Cryptosporidium parvum cgd7_3600   Hs17p, histone methylase
Dictyostelium discoideum DDB_G0287327   Skb1 family protein
Drosophila melanogaster Dmel_CG3730   capsuleen
Echinococcus granulosus EgrG_000795200   protein arginine N methyltransferase 5
Entamoeba histolytica EHI_158560   Skb1 methyltransferase, putative
Echinococcus multilocularis EmuJ_000795200   protein arginine N methyltransferase 5
Homo sapiens ENSG00000100462   protein arginine methyltransferase 5
Leishmania braziliensis LbrM.21.1830   arginine N-methyltransferase, type II, putative;with=GeneDB:Tb927.10.640
Leishmania donovani LdBPK_211690.1   methyltransferase-like protein
Leishmania infantum LinJ.21.1690   arginine N-methyltransferase, type II, putative;with=GeneDB:Tb927.10.640
Leishmania major LmjF.21.1450   arginine N-methyltransferase, type II, putative;with=GeneDB:Tb927.10.640
Leishmania mexicana LmxM.21.1450   methyltransferase-like protein
Loa Loa (eye worm) LOAG_08049   Skb1 methyltransferase
Mus musculus ENSMUSG00000023110   protein arginine N-methyltransferase 5
Neospora caninum NCLIV_052480   Protein arginine methyltransferase 5, related
Oryza sativa 4328251   Os02g0139200
Plasmodium berghei PBANKA_1137100   protein arginine N-methyltransferase 5, putative
Plasmodium falciparum PF3D7_1361000   protein arginine N-methyltransferase 5, putative
Plasmodium knowlesi PKNH_1110400   protein arginine N-methyltransferase 5, putative
Plasmodium vivax PVX_115010   protein arginine N-methyltransferase 5, putative
Plasmodium yoelii PY07031   protein methyltransferase-related
Saccharomyces cerevisiae YBR133C   Hsl7p
Schistosoma japonicum Sjp_0063090   ko:K00599 protein arginine N-methyltransferase 5 [EC:2.1.1.-], putative
Schistosoma mansoni Smp_171150   shk1 kinase-binding protein
Schmidtea mediterranea mk4.002031.05   Protein arginine methyltransferase 5-like protein
Trypanosoma brucei gambiense Tbg972.10.650   methyltransferase, putative
Trypanosoma brucei Tb927.10.640   arginine N-methyltransferase, type II
Trypanosoma congolense TcIL3000_10_500   methyltransferase, putative
Trypanosoma cruzi TcCLB.506853.30   arginine N-methyltransferase, type II, putative
Toxoplasma gondii TGME49_215560   histone arginine methyltransferase PRMT5
Theileria parva TP01_0100   kinase binding protein, putative
Trichomonas vaginalis TVAG_096150   shk1 kinase-binding protein, putative
Trichomonas vaginalis TVAG_254540   shk1 kinase-binding protein, putative

Essentiality

Sjp_0063090 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb927.10.640 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb927.10.640 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (6 days) alsford
Tb927.10.640 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb927.10.640 Trypanosoma brucei no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms alsford
CELE_C34E10.5 Caenorhabditis elegans embryonic lethal wormbase
TGME49_215560 Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens protein arginine methyltransferase 5 Compounds References
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Rattus norvegicus P2X purinoceptor 4 388 aa 25.6% 445 aa Compounds References
Rattus norvegicus P2X purinoceptor 2 472 aa 25.2% 449 aa Compounds References
Rattus norvegicus P2X purinoceptor 1 399 aa 27.7% 452 aa Compounds References
Rattus norvegicus P2X purinoceptor 6 379 aa 23.2% 315 aa Compounds References
Rattus norvegicus P2X purinoceptor 3 397 aa 25.6% 398 aa Compounds References
Rattus norvegicus P2X2/P2X3 receptor 397 aa 25.6% 398 aa Compounds References
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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Gene identifier Sjp_0063090 (Schistosoma japonicum), ko:K00599 protein arginine N-methyltransferase 5 [EC:2.1.1.-], putative
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