Detailed view for Sjp_0089010

Basic information

TDR Targets ID: 977635
Schistosoma japonicum, ko:K05696 protein tyrosine phosphatase, non-receptor type 1, putative
Source Database / ID:  Wormbase Parasite  

pI: 4.5418 | Length (AA): 484 | MW (Da): 54687 | Paralog Number: 1

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0

Druggability Group : DG

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00102   Protein-tyrosine phosphatase

Gene Ontology

Mouse over links to read term descriptions.
GO:0016791   phosphoric monoester hydrolase activity  
GO:0004725   protein tyrosine phosphatase activity  
GO:0016311   dephosphorylation  
GO:0006470   protein amino acid dephosphorylation  

Structural information

Modbase 3D models:

There are 4 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
9 461 2nlk (A) 831 1249 22.00 0.00000000026 1 1.01079 0.72
15 309 1l8k (A) 5 277 45.00 0.000000000086 1 1.16167 -0.96
15 341 2f71 (A) 3 298 44.00 0 1 1.21122 -1.1
67 306 2fh7 (A) 1703 1938 34.00 0 1 0.948094 -0.87

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_133865)

Species Accession Gene Product
Brugia malayi Bm1_36130   Protein-tyrosine phosphatase containing protein
Drosophila melanogaster Dmel_CG9181   Protein tyrosine phosphatase 61F
Echinococcus granulosus EgrG_000466900   tyrosine protein phosphatase non receptor type
Echinococcus multilocularis EmuJ_000466900   tyrosine protein phosphatase non receptor type
Homo sapiens ENSG00000196396   protein tyrosine phosphatase, non-receptor type 1
Loa Loa (eye worm) LOAG_06149   protein-tyrosine phosphatase
Mus musculus ENSMUSG00000027540   protein tyrosine phosphatase, non-receptor type 1
Schistosoma japonicum Sjp_0083730   expressed protein
Schistosoma japonicum Sjp_0089010   ko:K05696 protein tyrosine phosphatase, non-receptor type 1, putative
Schistosoma mansoni Smp_139930   protein tyrosine phosphatase non-receptor type nt1
Schmidtea mediterranea mk4.000841.05   Tyrosine-protein phosphatase non-receptor type 61F

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Rattus norvegicus Protein-tyrosine phosphatase 1B Compounds References
Homo sapiens protein tyrosine phosphatase, non-receptor type 1 Compounds References
Mus musculus protein tyrosine phosphatase, non-receptor type 1 Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Sjp_0089010 (Schistosoma japonicum), ko:K05696 protein tyrosine phosphatase, non-receptor type 1, putative
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