Detailed view for Sjp_0150020

Basic information

TDR Targets ID: 977840
Schistosoma japonicum, gsx family homeobox protein; serine/threonine kinase
Source Database / ID:  Wormbase Parasite  

pI: 8.2579 | Length (AA): 1189 | MW (Da): 135583 | Paralog Number: 1

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0

Druggability Group : DG

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00046   Homeobox domain
PF00069   Protein kinase domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0005524   ATP binding  
GO:0004672   protein kinase activity  
GO:0003677   DNA binding  
GO:0006468   protein amino acid phosphorylation  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

No model available for this protein in Modbase.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_133787)

Species Accession Gene Product
Brugia malayi Bm1_39765   Protein kinase domain containing protein
Caenorhabditis elegans CELE_W03G1.6   Protein PIG-1, isoform B
Echinococcus granulosus EgrG_000500200   maternal embryonic leucine zipper kinase
Echinococcus multilocularis EmuJ_000500200   maternal embryonic leucine zipper kinase
Homo sapiens ENSG00000165304   maternal embryonic leucine zipper kinase
Loa Loa (eye worm) LOAG_00732   CAMK/CAMKL/MELK protein kinase
Mus musculus ENSMUSG00000035683   maternal embryonic leucine zipper kinase
Schistosoma japonicum Sjp_0150020   gsx family homeobox protein; serine/threonine kinase
Schistosoma japonicum Sjp_0012410   ko:K08799 maternal embryonic leucine zipper kinase, putative
Schistosoma mansoni Smp_166150   serine/threonine kinase
Schmidtea mediterranea mk4.001893.00  
Trichomonas vaginalis TVAG_174020   CAMK family protein kinase
Trichomonas vaginalis TVAG_119830   CAMK family protein kinase
Trichomonas vaginalis TVAG_045990   CAMK family protein kinase

Essentiality

Sjp_0150020 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_W03G1.6 Caenorhabditis elegans larval lethal wormbase
Show/Hide essentiality data references
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens maternal embryonic leucine zipper kinase Compounds References
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Homo sapiens Cyclin-dependent kinase 1/cyclin B1 297 aa 29.4% 286 aa Compounds References
Rattus norvegicus Serine/threonine-protein kinase pim-3 326 aa 26.1% 291 aa Compounds References
Plasmodium falciparum (isolate 3D7) Cell division control protein 2 homolog 288 aa 26.7% 288 aa Compounds References
Rattus norvegicus MAP kinase p38 alpha 360 aa 27.3% 304 aa Compounds References
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

No user comments are available for this gene. Log in to add comments, or register.

Enter your comment

User ()
Gene identifier Sjp_0150020 (Schistosoma japonicum), gsx family homeobox protein; serine/threonine kinase
Title for this comment
Comment