Detailed view for Sjp_0101420

Basic information

TDR Targets ID: 977857
Schistosoma japonicum, ko:K01672 carbonic anhydrase [EC4.2.1.1], putative
Source Database / ID:  Wormbase Parasite  

pI: 7.7338 | Length (AA): 322 | MW (Da): 36095 | Paralog Number: 3

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0

Druggability Group : DG

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00194   Eukaryotic-type carbonic anhydrase

Gene Ontology

Mouse over links to read term descriptions.
GO:0008270   zinc ion binding  
GO:0004089   carbonate dehydratase activity  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 4 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
23 294 2w2j (A) 23 290 25.00 0.00000000013 1 1.05115 0.15
31 301 6b00 (A) 7 266 30.00 0 1 1.21904 -0.55
59 290 5ezt (X) 24 255 35.00 0 1 1.09414 -0.32
59 293 1keq (A) 25 260 32.00 0 1 1.19989 -0.79

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_132345)

Species Accession Gene Product
Brugia malayi Bm1_46870   Carbonic anhydrase like protein 2 precursor
Caenorhabditis elegans CELE_D1022.8   Protein CAH-2
Drosophila melanogaster Dmel_CG32698   CG32698 gene product from transcript CG32698-RD
Drosophila melanogaster Dmel_CG1402   CG1402 gene product from transcript CG1402-RC
Echinococcus granulosus EgrG_000108300   carbonic anhydrase
Echinococcus granulosus EgrG_000904400   carbonic anhydrase
Echinococcus multilocularis EmuJ_000904400   carbonic anhydrase
Echinococcus multilocularis EmuJ_000108300   carbonic anhydrase
Homo sapiens ENSG00000154975   carbonic anhydrase X
Loa Loa (eye worm) LOAG_02148   hypothetical protein
Mus musculus ENSMUSG00000056158   carbonic anhydrase 10
Schistosoma japonicum Sjp_0316670   Carbonic anhydrase-related protein 10, putative
Schistosoma japonicum Sjp_0114290   Carbonic anhydrase-related protein 10, putative
Schistosoma japonicum Sjp_0101420   ko:K01672 carbonic anhydrase [EC4.2.1.1], putative
Schistosoma japonicum Sjp_0210440   Carbonic anhydrase-related protein 10, putative
Schistosoma mansoni Smp_135470   carbonic anhydrase-related
Schmidtea mediterranea mk4.018146.01  
Schmidtea mediterranea mk4.015300.00  
Schmidtea mediterranea mk4.023065.01  

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Sulfurihydrogenibium sp. (strain YO3AOP1) Carbonate dehydratase 246 aa 26.4% 265 aa Compounds References
Astrosclera willeyana Astrosclerin-3 292 aa 27.0% 244 aa Compounds References
Stylophora pistillata Carbonic anhydrase 316 aa 31.2% 285 aa Compounds References
Bos taurus Carbonic anhydrase IV 312 aa 26.9% 253 aa Compounds References
Rattus norvegicus Carbonic anhydrase II 260 aa 32.5% 265 aa Compounds References
Bos taurus Carbonic anhydrase 3 260 aa 27.8% 248 aa Compounds References
Bos taurus Carbonic anhydrase II 260 aa 32.8% 265 aa Compounds References
Thiomicrospira crunogena (strain XCL-2) Carbonic anhydrase, alpha family 315 aa 26.3% 255 aa Compounds References
Bos taurus Carbonic anhydrase 312 aa 26.9% 253 aa Compounds References
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Sjp_0101420 (Schistosoma japonicum), ko:K01672 carbonic anhydrase [EC4.2.1.1], putative
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