Detailed view for Sjp_0067420

Basic information

TDR Targets ID: 978157
Schistosoma japonicum, Thyroid hormone receptor alpha, putative
Source Database / ID:  Wormbase Parasite  

pI: 5.4012 | Length (AA): 366 | MW (Da): 40760 | Paralog Number: 3

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0

Druggability Group : DG

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00104   Ligand-binding domain of nuclear hormone receptor

Gene Ontology

Mouse over links to read term descriptions.
GO:0006355   regulation of transcription, DNA-dependent  
GO:0005634   nucleus  
GO:0004887   thyroid hormone receptor activity  
GO:0003707   steroid hormone receptor activity  
GO:0003677   DNA binding  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 4 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
11 329 3uvv (A) 150 403 31.00 0 1 0.905273 -0.04
61 120 4nqa (B) 261 317 39.00 0.36 0.42 0.484584 0.42
165 310 3n00 (A) 458 608 18.00 0 0.6 0.5913 -0.65
175 310 4oiv (B) 330 457 22.00 0 1 0.564903 -0.45

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_134830)

Species Accession Gene Product
Echinococcus granulosus EgrG_000362200   Mitotic checkpoint protein PRCC C terminal
Echinococcus multilocularis EmuJ_000362200   Mitotic checkpoint protein PRCC, C terminal
Echinococcus multilocularis EmuJ_000317100   thyroid hormone receptor alpha
Homo sapiens ENSG00000151090   thyroid hormone receptor, beta
Mus musculus ENSMUSG00000021779   thyroid hormone receptor beta
Schistosoma japonicum Sjp_0050210   ko:K08362 nuclear receptor, subfamily 1, group A, member 2, putative
Schistosoma japonicum Sjp_0027230   Thyroid hormone receptor alpha, putative
Schistosoma japonicum Sjp_0212430   expressed protein
Schistosoma japonicum Sjp_0067420   Thyroid hormone receptor alpha, putative
Schistosoma mansoni Smp_134490   thyroid hormone receptor
Schistosoma mansoni Smp_134480   hypothetical protein
Schistosoma mansoni Smp_174260   thyroid hormone receptor
Schmidtea mediterranea mk4.000522.07   Nuclear receptor subfamily 6 group A member 1
Schmidtea mediterranea mk4.000180.10  

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Rattus norvegicus Thyroid hormone receptor beta-1 Compounds References
Homo sapiens thyroid hormone receptor, beta Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Sjp_0067420 (Schistosoma japonicum), Thyroid hormone receptor alpha, putative
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