Detailed view for Sjp_0210440

Basic information

TDR Targets ID: 978372
Schistosoma japonicum, Carbonic anhydrase-related protein 10, putative
Source Database / ID:  Wormbase Parasite  

pI: 7.0834 | Length (AA): 316 | MW (Da): 35726 | Paralog Number: 3

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 1

Druggability Group : DG

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00194   Eukaryotic-type carbonic anhydrase

Gene Ontology

Mouse over links to read term descriptions.
GO:0008270   zinc ion binding  
GO:0004089   carbonate dehydratase activity  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

No model available for this protein in Modbase.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_132345)

Species Accession Gene Product
Brugia malayi Bm1_46870   Carbonic anhydrase like protein 2 precursor
Caenorhabditis elegans CELE_D1022.8   Protein CAH-2
Drosophila melanogaster Dmel_CG32698   CG32698 gene product from transcript CG32698-RD
Drosophila melanogaster Dmel_CG1402   CG1402 gene product from transcript CG1402-RC
Echinococcus granulosus EgrG_000108300   carbonic anhydrase
Echinococcus granulosus EgrG_000904400   carbonic anhydrase
Echinococcus multilocularis EmuJ_000904400   carbonic anhydrase
Echinococcus multilocularis EmuJ_000108300   carbonic anhydrase
Homo sapiens ENSG00000154975   carbonic anhydrase X
Loa Loa (eye worm) LOAG_02148   hypothetical protein
Mus musculus ENSMUSG00000056158   carbonic anhydrase 10
Schistosoma japonicum Sjp_0316670   Carbonic anhydrase-related protein 10, putative
Schistosoma japonicum Sjp_0114290   Carbonic anhydrase-related protein 10, putative
Schistosoma japonicum Sjp_0101420   ko:K01672 carbonic anhydrase [EC4.2.1.1], putative
Schistosoma japonicum Sjp_0210440   Carbonic anhydrase-related protein 10, putative
Schistosoma mansoni Smp_135470   carbonic anhydrase-related
Schmidtea mediterranea mk4.018146.01  
Schmidtea mediterranea mk4.015300.00  
Schmidtea mediterranea mk4.023065.01  

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Astrosclera willeyana Astrosclerin-3 292 aa 28.1% 235 aa Compounds References
Bos taurus Carbonic anhydrase II 260 aa 31.1% 264 aa Compounds References
Thiomicrospira crunogena (strain XCL-2) Carbonic anhydrase, alpha family 315 aa 25.5% 263 aa Compounds References
Sulfurihydrogenibium sp. (strain YO3AOP1) Carbonate dehydratase 246 aa 34.1% 232 aa Compounds References
Rattus norvegicus Carbonic anhydrase II 260 aa 30.0% 270 aa Compounds References
Bos taurus Carbonic anhydrase 3 260 aa 28.5% 267 aa Compounds References
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

No user comments are available for this gene. Log in to add comments, or register.

Enter your comment

User ()
Gene identifier Sjp_0210440 (Schistosoma japonicum), Carbonic anhydrase-related protein 10, putative
Title for this comment
Comment