Detailed view for Sjp_0134380

Basic information

TDR Targets ID: 978854
Schistosoma japonicum, Serine/threonine-protein kinase Nek6, putative
Source Database / ID:  Wormbase Parasite  

pI: 5.7081 | Length (AA): 144 | MW (Da): 16228 | Paralog Number: 1

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 1

Druggability Group : DG

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00069   Protein kinase domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0005524   ATP binding  
GO:0004672   protein kinase activity  
GO:0006468   protein amino acid phosphorylation  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 4 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
6 120 2wqm (A) 166 288 56.00 0 1 1.2922 0.37
26 62 5ax9 (A) 172 227 57.00 0.00041 0.45 0.620141 0.99
29 108 2xk7 (A) 177 253 51.00 0.00000000012 0.97 1.04784 -0.56
30 142 5uab (A) 1245 1355 22.00 0 0.75 1.10881 -0.55

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_131134)

Species Accession Gene Product
Brugia malayi Bm1_31880   Serine/threonine-protein kinase Nek7
Caenorhabditis elegans CELE_F19H6.1   Protein NEKL-3
Chlamydia trachomatis CT_673   serine/threonine protein kinase
Homo sapiens ENSG00000119408   NIMA-related kinase 6
Homo sapiens ENSG00000151414   NIMA-related kinase 7
Loa Loa (eye worm) LOAG_07567   NEK/NEK6 protein kinase
Mus musculus ENSMUSG00000026393   NIMA (never in mitosis gene a)-related expressed kinase 7
Mus musculus ENSMUSG00000026749   NIMA (never in mitosis gene a)-related expressed kinase 6
Schistosoma japonicum Sjp_0050470   ko:K08857 NIMA (never in mitosis gene a)-related kinase, putative
Schistosoma japonicum Sjp_0134380   Serine/threonine-protein kinase Nek6, putative
Schistosoma mansoni Smp_097940   serine/threonine protein kinase
Schmidtea mediterranea mk4.019406.00   Serine/threonine kinase
Schmidtea mediterranea mk4.013136.00   Molting protein MLT-1
Schmidtea mediterranea mk4.000474.04   LD04361p

Essentiality

Sjp_0134380 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_F19H6.1 Caenorhabditis elegans slow growth wormbase
Show/Hide essentiality data references
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens NIMA-related kinase 6 Compounds References
Homo sapiens NIMA-related kinase 7 Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Sjp_0134380 (Schistosoma japonicum), Serine/threonine-protein kinase Nek6, putative
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