Detailed view for Sjp_0216310

Basic information

TDR Targets ID: 978900
Schistosoma japonicum, Casein kinase I isoform alpha, putative
Source Database / ID:  Wormbase Parasite  

pI: 9.266 | Length (AA): 428 | MW (Da): 48556 | Paralog Number: 0

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0

Druggability Group : DG

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00069   Protein kinase domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0005524   ATP binding  
GO:0004672   protein kinase activity  
GO:0006468   protein amino acid phosphorylation  

Metabolic Pathways

Ribosome biogenesis in eukaryotes (KEGG)

Structural information

Modbase 3D models:

No model available for this protein in Modbase.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_246539)

Species Accession Gene Product
Schistosoma japonicum Sjp_0216310   Casein kinase I isoform alpha, putative
Schistosoma mansoni Smp_168120   peptidase
Schmidtea mediterranea mk4.019126.01   Protein kinase

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Bos taurus Casein kinase I isoform alpha 325 aa 64.4% 306 aa Compounds References
Sus scrofa Casein kinase I isoform alpha 125 aa 64.1% 128 aa Compounds References
Rattus norvegicus Casein kinase I delta 415 aa 55.7% 357 aa Compounds References
Sus scrofa Casein kinase 1, delta tv1 415 aa 55.7% 357 aa Compounds References
Plasmodium falciparum (isolate 3D7) Cell division control protein 2 homolog 288 aa 25.9% 274 aa Compounds References
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Sjp_0216310 (Schistosoma japonicum), Casein kinase I isoform alpha, putative
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