Detailed view for Sjp_0092600

Basic information

TDR Targets ID: 978907
Schistosoma japonicum, Calpain-1 catalytic subunit, putative
Source Database / ID:  Wormbase Parasite  

pI: 6.4707 | Length (AA): 176 | MW (Da): 19620 | Paralog Number: 2

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0

Druggability Group : DG

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF13405   EF-hand domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0005509   calcium ion binding  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 5 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
27 72 1nm3 (A) 38 87 43.00 0.98 0.53 0.615957 0.41
36 133 4okh (A) 716 813 30.00 0 0.95 1.0392 -1.08
38 122 4q04 (A) 110 194 20.00 0 0.97 0.904914 -1.46
47 103 2ami (A) 12 69 25.00 0.021 0.73 0.760814 -1.31
47 117 5joj (A) 14 95 20.00 0 1 0.606914 -0.75

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_127139)

Species Accession Gene Product
Arabidopsis thaliana AT1G55350   calpain-type cysteine protease DEK1
Brugia malayi Bm1_21035   calpain family protein 1
Brugia malayi Bm1_30345   calpain family protein 1
Caenorhabditis elegans CELE_C06G4.2   Protein CLP-1, isoform C
Caenorhabditis elegans CELE_Y39A3CL.5   Protein CLP-4, isoform A
Caenorhabditis elegans CELE_Y47H10A.1   Protein CLP-3
Caenorhabditis elegans CELE_Y77E11A.11   Protein CLP-7
Caenorhabditis elegans CELE_Y77E11A.10   Protein CLP-6
Drosophila melanogaster Dmel_CG3692   Calpain C
Drosophila melanogaster Dmel_CG8107   Calpain-B
Drosophila melanogaster Dmel_CG7563   Calpain-A
Echinococcus granulosus EgrG_000319100   family C2 unassigned peptidase C02 family
Echinococcus granulosus EgrG_000911200   calpain A
Echinococcus multilocularis EmuJ_000319100   family C2 unassigned peptidase (C02 family)
Echinococcus multilocularis EmuJ_000026300   calpain family protein 1, d
Echinococcus multilocularis EmuJ_000911200   calpain A
Homo sapiens ENSG00000137225   calpain 11
Homo sapiens ENSG00000203697   calpain 8
Homo sapiens ENSG00000014216   calpain 1, (mu/I) large subunit
Homo sapiens ENSG00000092529   calpain 3, (p94)
Homo sapiens ENSG00000162909   calpain 2, (m/II) large subunit
Homo sapiens ENSG00000135773   calpain 9
Loa Loa (eye worm) LOAG_13979   calpain family protein 1
Loa Loa (eye worm) LOAG_11178   hypothetical protein
Loa Loa (eye worm) LOAG_13307   hypothetical protein
Loa Loa (eye worm) LOAG_11409   calpain family protein 1
Loa Loa (eye worm) LOAG_14606   hypothetical protein
Loa Loa (eye worm) LOAG_13308   hypothetical protein
Mus musculus ENSMUSG00000031981   calpain 9
Mus musculus ENSMUSG00000058626   calpain 11
Mus musculus ENSMUSG00000026509   calpain 2
Mus musculus ENSMUSG00000038599   calpain 8
Mus musculus ENSMUSG00000079110   calpain 3
Mus musculus ENSMUSG00000024942   calpain 1
Oryza sativa 4330484   Os02g0709400
Onchocerca volvulus OVOC13412  
Schistosoma japonicum Sjp_0205060   Calpain-A, putative
Schistosoma japonicum Sjp_0300430   ko:K08585 calpain, invertebrate, putative
Schistosoma japonicum Sjp_0092600   Calpain-1 catalytic subunit, putative
Schistosoma mansoni Smp_003980   family C2 unassigned peptidase (C02 family)
Schistosoma mansoni Smp_089460.2   family C2 unassigned peptidase (C02 family)
Schistosoma mansoni Smp_089460.1   family C2 unassigned peptidase (C02 family)
Schmidtea mediterranea mk4.012278.01   Family C2 unassigned peptidase
Schmidtea mediterranea mk4.012336.00   Family C2 unassigned peptidase
Schmidtea mediterranea mk4.005460.00  
Schmidtea mediterranea mk4.008380.01  
Schmidtea mediterranea mk4.001840.06  
Schmidtea mediterranea mk4.001840.05  
Schmidtea mediterranea mk4.001840.04  
Schmidtea mediterranea mk4.009130.00  
Schmidtea mediterranea mk4.034423.00  
Schmidtea mediterranea mk4.001141.01  
Schmidtea mediterranea mk4.025451.00  
Schmidtea mediterranea mk4.019838.04   Calpain clp-1
Schmidtea mediterranea mk4.000932.03   Family C2 unassigned peptidase
Schmidtea mediterranea mk4.000540.03  

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Sus scrofa Calpain 2 Compounds References
Gallus gallus Calpain 1/2 Compounds References
Homo sapiens calpain 2, (m/II) large subunit Compounds References
Rattus norvegicus Calpain 1 Compounds References
Sus scrofa Calpain 1 Compounds References
Homo sapiens calpain 1, (mu/I) large subunit Compounds References
Bos taurus Calpain 2 Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Sjp_0092600 (Schistosoma japonicum), Calpain-1 catalytic subunit, putative
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