pI: 5.3797 |
Length (AA): 245 |
MW (Da): 27298 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
PDB Structures:
Ortholog group members (OG5_129545)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT5G17690 | chromo domain-containing protein LHP1 |
Brugia malayi | Bm1_45290 | Heterochromatin protein 1 |
Caenorhabditis elegans | CELE_K08H2.6 | Protein HPL-1 |
Caenorhabditis elegans | CELE_K01G5.2 | Protein HPL-2, isoform A |
Dictyostelium discoideum | DDB_G0282987 | HP1-like protein |
Dictyostelium discoideum | DDB_G0283023 | HP1-like protein |
Dictyostelium discoideum | DDB_G0270198 | HP1-like protein |
Drosophila melanogaster | Dmel_CG7041 | Heterochromatin Protein 1b |
Drosophila melanogaster | Dmel_CG8409 | Suppressor of variegation 205 |
Drosophila melanogaster | Dmel_CG43352 | Heterochromatin Protein 1L chromoshadow domain |
Echinococcus granulosus | EgrG_000492600 | chromobox protein 1 |
Echinococcus granulosus | EgrG_000830000 | chromobox protein 1 |
Echinococcus multilocularis | EmuJ_000492600 | chromobox protein 1 |
Echinococcus multilocularis | EmuJ_000830000 | chromobox protein 1 |
Homo sapiens | ENSG00000108468 | chromobox homolog 1 |
Loa Loa (eye worm) | LOAG_03522 | heterochromatin protein 1 |
Loa Loa (eye worm) | LOAG_12932 | hypothetical protein |
Mus musculus | ENSMUSG00000018666 | chromobox 1 |
Onchocerca volvulus | OVOC8431 | Heterochromatin protein 1 homolog |
Onchocerca volvulus | OVOC5537 |
|
Schistosoma japonicum | Sjp_0217300 | Chromobox protein homolog 5, putative |
Schistosoma mansoni | Smp_179650.1 | chromobox protein |
Schistosoma mansoni | Smp_179650.2 | chromobox protein |
Schmidtea mediterranea | mk4.005953.00 | Putative chromobox protein |
Theileria parva | TP03_0014 | hypothetical protein |
Trichomonas vaginalis | TVAG_160080 | chromobox protein, putative |
Trichomonas vaginalis | TVAG_240130 | chromobox protein, putative |
Trichomonas vaginalis | TVAG_021570 | chromobox protein, putative |
Trichomonas vaginalis | TVAG_293880 | chromobox protein, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
CELE_K08H2.6 | Caenorhabditis elegans | larval arrest | wormbase |
CELE_K01G5.2 | Caenorhabditis elegans | larval lethal | wormbase |
CELE_K01G5.2 | Caenorhabditis elegans | slow growth | wormbase |
CELE_K01G5.2 | Caenorhabditis elegans | sterile | wormbase |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Species | Known druggable target | Linked compounds | Reference |
---|---|---|---|
Homo sapiens | chromobox homolog 1 | Compounds | References |