Detailed view for Sjp_0073490

Basic information

TDR Targets ID: 979228
Schistosoma japonicum, IPR000276,Rhodopsin-like GPCR superfamily,domain-containing
Source Database / ID:  Wormbase Parasite  

pI: 8.374 | Length (AA): 441 | MW (Da): 50391 | Paralog Number: 1

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 7

Druggability Group : DG

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00001   7 transmembrane receptor (rhodopsin family)

Gene Ontology

Mouse over links to read term descriptions.
GO:0016021   integral to membrane  
GO:0004930   G-protein coupled receptor activity  
GO:0007186   G-protein coupled receptor protein signaling pathway  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 4 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
68 426 3uon (A) 36 451 25.00 0.013 0.77 0.782609 0.71
136 225 6ch2 (D) 22 138 29.00 0.95 0.21 0.414245 -0.28
331 414 4p6v (E) 52 130 36.00 0.079 0.06 0.186609 1.41
400 430 2lnl (A) 290 320 23.00 0.23 0.03 0.00965455 2.68

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_138410)

Species Accession Gene Product
Brugia malayi Bm1_29620   AT19640p
Caenorhabditis elegans CELE_F57B7.1   Protein DMSR-1, isoform B
Caenorhabditis elegans CELE_C35A11.1   Protein DMSR-7
Drosophila melanogaster Dmel_CG43745   Myosuppressin receptor 2
Drosophila melanogaster Dmel_CG8985   Myosuppressin receptor 1
Echinococcus granulosus EgrG_000892500   dro:myosuppressin receptor
Echinococcus granulosus EgrG_000070900   dro:myosuppressin receptor
Echinococcus granulosus EgrG_000431100   dro:myosuppressin receptor
Echinococcus multilocularis EmuJ_000892500   dro:myosuppressin receptor
Echinococcus multilocularis EmuJ_000431100   dro:myosuppressin receptor
Echinococcus multilocularis EmuJ_000070900   dro:myosuppressin receptor
Loa Loa (eye worm) LOAG_12438   hypothetical protein
Loa Loa (eye worm) LOAG_11096   hypothetical protein
Loa Loa (eye worm) LOAG_03072   hypothetical protein
Schistosoma japonicum Sjp_0073490   IPR000276,Rhodopsin-like GPCR superfamily,domain-containing
Schistosoma japonicum Sjp_0038900   IPR000276,Rhodopsin-like GPCR superfamily,domain-containing
Schistosoma mansoni Smp_173010   dro/myosuppressin receptor
Schmidtea mediterranea mk4.013160.00  
Schmidtea mediterranea mk4.017680.00  
Schmidtea mediterranea mk4.001225.04  
Schmidtea mediterranea mk4.002460.05   Putative dro/myosuppressin receptor

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Chlorocebus aethiops Dopamine D3 receptor 400 aa 21.1% 412 aa Compounds References
Gorilla gorilla Serotonin 1b (5-HT1b) receptor 390 aa 23.6% 369 aa Compounds References
Rattus norvegicus Serotonin 1b (5-HT1b) receptor 386 aa 24.0% 363 aa Compounds References
Rattus norvegicus Serotonin 1f (5-HT1f) receptor 366 aa 21.9% 398 aa Compounds References
Cricetulus griseus 5-hydroxytryptamine receptor 1B 386 aa 24.0% 363 aa Compounds References
Rattus norvegicus Serotonin (5-HT) receptor 386 aa 24.0% 363 aa Compounds References
Cavia porcellus Cholecystokinin A receptor 430 aa 22.7% 383 aa Compounds References
Rattus norvegicus Serotonin 1 (5-HT1) receptor 366 aa 21.9% 398 aa Compounds References
Cavia porcellus Serotonin 1d (5-HT1d) receptor 376 aa 24.0% 371 aa Compounds References
Rattus norvegicus Serotonin 1a (5-HT1a) receptor 422 aa 21.1% 417 aa Compounds References
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Sjp_0073490 (Schistosoma japonicum), IPR000276,Rhodopsin-like GPCR superfamily,domain-containing
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