Detailed view for Sjp_0054180

Basic information

TDR Targets ID: 979323
Schistosoma japonicum, ko:K06069 atypical protein kinase C, putative
Source Database / ID:  Wormbase Parasite  

pI: 6.3067 | Length (AA): 657 | MW (Da): 74290 | Paralog Number: 0

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0

Druggability Group : DG

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00069   Protein kinase domain
PF00130   Phorbol esters/diacylglycerol binding domain (C1 domain)
PF00433   Protein kinase C terminal domain
PF00564   PB1 domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0035556   GO:intracellular signal transduction  

GO:0005524   ATP binding  
GO:0005515   protein binding  
GO:0004674   protein serine/threonine kinase activity  
GO:0004672   protein kinase activity  
GO:0006468   protein amino acid phosphorylation  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 6 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
1 74 4mjs (A) 27 100 40.00 0.00000016 1 0.666205 -1.12
1 71 1wmh (A) 28 98 48.00 0 1 0.782732 -1.11
106 155 1ptq (A) 231 280 32.00 0.0023 0.47 0.30562 0.89
106 650 3pfq (A) 102 667 41.00 0 1 1.18029 0.34
309 650 3zh8 (A) 240 581 72.00 0 1 1.29574 -0.83
311 645 4otd (A) 618 944 42.00 0 1 1.03507 -0.93

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_131830)

Species Accession Gene Product
Brugia malayi Bm1_03335   protein kinase C3,putative
Caenorhabditis elegans CELE_F09E5.1   Protein PKC-3
Drosophila melanogaster Dmel_CG42783   atypical protein kinase C
Echinococcus granulosus EgrG_000455600   protein kinase c iota type
Echinococcus multilocularis EmuJ_000455600   protein kinase c iota type
Homo sapiens ENSG00000163558   protein kinase C, iota
Homo sapiens ENSG00000067606   protein kinase C, zeta
Loa Loa (eye worm) LOAG_01340   AGC/PKC/IOTA protein kinase
Mus musculus ENSMUSG00000029053   protein kinase C, zeta
Mus musculus ENSMUSG00000037643   protein kinase C, iota
Schistosoma japonicum Sjp_0054180   ko:K06069 atypical protein kinase C, putative
Schistosoma mansoni Smp_096310   atypical protein kinase C
Schmidtea mediterranea mk4.000800.06   Serine/threonine kinase

Essentiality

Sjp_0054180 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_F09E5.1 Caenorhabditis elegans embryonic lethal wormbase
Show/Hide essentiality data references
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens protein kinase C, iota Compounds References
Rattus norvegicus Protein kinase C (PKC) Compounds References
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Oryctolagus cuniculus cAMP-dependent protein kinase alpha-catalytic subunit 351 aa 37.0% 303 aa Compounds References
Rattus norvegicus cAMP-dependent protein kinase alpha-catalytic subunit 351 aa 38.0% 303 aa Compounds References
Bos taurus cAMP-dependent protein kinase alpha-catalytic subunit 351 aa 38.0% 303 aa Compounds References
Rattus norvegicus Mitogen-activated protein kinase 1 358 aa 24.1% 332 aa Compounds References
Xenopus laevis Aurora kinase B-B 368 aa 26.1% 348 aa Compounds References
Schizosaccharomyces pombe 972h- Casein kinase II subunit alpha 332 aa 23.9% 309 aa Compounds References
Xenopus laevis Aurora kinase B-A 361 aa 26.2% 347 aa Compounds References
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Sjp_0054180 (Schistosoma japonicum), ko:K06069 atypical protein kinase C, putative
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