Detailed view for Sjp_0075990

Basic information

TDR Targets ID: 979326
Schistosoma japonicum, ko:K02649 phosphoinositide-3-kinase, regulatory subunit, putative
Source Database / ID:  Wormbase Parasite  

pI: 6.9428 | Length (AA): 342 | MW (Da): 39150 | Paralog Number: 4

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0

Druggability Group : DG

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00017   SH2 domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0005942   phosphoinositide 3-kinase complex  
GO:0035014   phosphoinositide 3-kinase regulator activity  

Metabolic Pathways

EGFR tyrosine kinase inhibitor resistance (KEGG)
Endocrine resistance (KEGG)
Platinum drug resistance (KEGG)
ErbB signaling pathway (KEGG)
Ras signaling pathway (KEGG)
Rap1 signaling pathway (KEGG)
cAMP signaling pathway (KEGG)
Chemokine signaling pathway (KEGG)
HIF-1 signaling pathway (KEGG)
FoxO signaling pathway (KEGG)
Phosphatidylinositol signaling system (KEGG)
Sphingolipid signaling pathway (KEGG)
Phospholipase D signaling pathway (KEGG)
Regulation of autophagy (KEGG)
mTOR signaling pathway (KEGG)
PI3K-Akt signaling pathway (KEGG)
AMPK signaling pathway (KEGG)
Apoptosis (KEGG)
Longevity regulating pathway (KEGG)
Longevity regulating pathway - multiple species (KEGG)
Cellular senescence (KEGG)
Axon guidance (KEGG)
VEGF signaling pathway (KEGG)
Osteoclast differentiation (KEGG)
Focal adhesion (KEGG)
Signaling pathways regulating pluripotency of stem cells (KEGG)
Platelet activation (KEGG)
Toll-like receptor signaling pathway (KEGG)
Jak-STAT signaling pathway (KEGG)
Natural killer cell mediated cytotoxicity (KEGG)
T cell receptor signaling pathway (KEGG)
B cell receptor signaling pathway (KEGG)
Fc epsilon RI signaling pathway (KEGG)
Fc gamma R-mediated phagocytosis (KEGG)
TNF signaling pathway (KEGG)
Leukocyte transendothelial migration (KEGG)
Neurotrophin signaling pathway (KEGG)
Cholinergic synapse (KEGG)
Inflammatory mediator regulation of TRP channels (KEGG)
Regulation of actin cytoskeleton (KEGG)
Insulin signaling pathway (KEGG)
Progesterone-mediated oocyte maturation (KEGG)
Estrogen signaling pathway (KEGG)
Prolactin signaling pathway (KEGG)
Thyroid hormone signaling pathway (KEGG)
Regulation of lipolysis in adipocytes (KEGG)
Type II diabetes mellitus (KEGG)
Insulin resistance (KEGG)
Non-alcoholic fatty liver disease (NAFLD) (KEGG)
AGE-RAGE signaling pathway in diabetic complications (KEGG)
Aldosterone-regulated sodium reabsorption (KEGG)
Carbohydrate digestion and absorption (KEGG)
Bacterial invasion of epithelial cells (KEGG)
Chagas disease (KEGG)
Amoebiasis (KEGG)
Hepatitis C (KEGG)
Hepatitis B (KEGG)
Measles (KEGG)
Influenza A (KEGG)
Human papillomavirus infection (KEGG)
HTLV-I infection (KEGG)
Kaposi's sarcoma-associated herpesvirus infection (KEGG)
Epstein-Barr virus infection (KEGG)
Pathways in cancer (KEGG)
Viral carcinogenesis (KEGG)
Proteoglycans in cancer (KEGG)
Colorectal cancer (KEGG)
Renal cell carcinoma (KEGG)
Pancreatic cancer (KEGG)
Endometrial cancer (KEGG)
Glioma (KEGG)
Prostate cancer (KEGG)
Melanoma (KEGG)
Chronic myeloid leukemia (KEGG)
Acute myeloid leukemia (KEGG)
Small cell lung cancer (KEGG)
Non-small cell lung cancer (KEGG)
Breast cancer (KEGG)
Central carbon metabolism in cancer (KEGG)
Choline metabolism in cancer (KEGG)
Fluid shear stress and atherosclerosis (KEGG)

Structural information

Modbase 3D models:

There are 5 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
58 341 4l23 (B) 323 593 23.00 0 0.93 1.00044 0.64
58 108 4tzi (A) 119 170 43.00 0.015 1 0.61386 -0.06
59 166 5gji (A) 324 430 43.00 0 1 0.924316 -1.41
63 331 5swg (B) 328 596 30.00 0.00000000029 1 1.00016 0.47
69 129 5sxj (B) 334 394 53.00 0.48 0.68 0.387186 0.88

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_130060)

Species Accession Gene Product
Brugia malayi Bm1_37505   SH2 domain containing protein
Caenorhabditis elegans CELE_Y110A7A.10   Protein AAP-1
Drosophila melanogaster Dmel_CG2699   CG2699 gene product from transcript CG2699-RE
Echinococcus granulosus EgrG_000503600   phosphatidylinositol 3 kinase regulatory subunit
Echinococcus granulosus EgrG_000503700   expressed conserved protein
Echinococcus multilocularis EmuJ_000503700   expressed conserved protein
Echinococcus multilocularis EmuJ_000503600   phosphatidylinositol 3 kinase regulatory subunit
Homo sapiens ENSG00000105647   phosphoinositide-3-kinase, regulatory subunit 2 (beta)
Homo sapiens ENSG00000145675   phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
Homo sapiens ENSG00000117461   phosphoinositide-3-kinase, regulatory subunit 3 (gamma)
Loa Loa (eye worm) LOAG_02437   hypothetical protein
Mus musculus ENSMUSG00000028698   phosphatidylinositol 3 kinase, regulatory subunit, polypeptide 3 (p55)
Mus musculus ENSMUSG00000041417   phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha)
Mus musculus ENSMUSG00000031834   phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 2 (p85 beta)
Schistosoma japonicum Sjp_0119120   IPR000980,SH2 motif;IPR001720,PI3 kinase, P85 regulatory subunit,domain-containing
Schistosoma japonicum Sjp_0075990   ko:K02649 phosphoinositide-3-kinase, regulatory subunit, putative
Schistosoma japonicum Sjp_0131770   IPR000980,SH2 motif;IPR000198,RhoGAP;IPR008936,Rho GTPase activation protein,domain-containing
Schistosoma japonicum Sjp_0041810   IPR000198,RhoGAP;IPR008936,Rho GTPase activation protein,domain-containing
Schistosoma japonicum Sjp_0207440   expressed protein
Schistosoma mansoni Smp_162350   hypothetical protein
Schmidtea mediterranea mk4.005666.00   Phosphoinositide 3-kinase adapter subunit

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens phosphoinositide-3-kinase, regulatory subunit 1 (alpha) Compounds References
Homo sapiens phosphoinositide-3-kinase, regulatory subunit 2 (beta) Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Sjp_0075990 (Schistosoma japonicum), ko:K02649 phosphoinositide-3-kinase, regulatory subunit, putative
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