Detailed view for Tb927.9.13300

Basic information

TDR Targets ID: 979664
Trypanosoma brucei, Ring finger domain containing protein, putative
Source Database / ID:  TriTrypDB  GeneDB

pI: 9.7287 | Length (AA): 488 | MW (Da): 54886 | Paralog Number: 0

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00612   IQ calmodulin-binding motif
PF13639   Ring finger domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0005515   protein binding  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 5 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
168 235 1mm2 (A) 2 61 28.00 0 1 0.195478 0.46
168 234 5fer (A) 6 65 38.00 0.91 0.49 0.117776 0.79
171 236 2ecv (A) 19 74 27.00 0 0.44 0.247675 -0.06
174 230 2ect (A) 18 61 32.00 0 0.74 0.213565 -0.29
454 514 2lxh (C) 330 378 41.00 0.17 0.27 0.27437 0.29

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Mid 40-60% percentile Procyclic, Bloodstream Form. Siegel TN
Show/Hide expression data references
  • Siegel TN Genome-wide analysis of mRNA abundance in two life-cycle stages of Trypanosoma brucei and identification of splicing and polyadenylation sites.

Orthologs

Ortholog group members (OG5_132180)

Species Accession Gene Product
Giardia lamblia GL50803_4897   hypothetical protein
Homo sapiens ENSG00000105982   ring finger protein 32
Leishmania braziliensis LbrM.34.2450   hypothetical protein, conserved
Leishmania donovani LdBPK_352560.1   Ring finger domain containing protein, putative
Leishmania infantum LinJ.35.2560   hypothetical protein, conserved
Leishmania major LmjF.35.2520   hypothetical protein, conserved
Leishmania mexicana LmxM.34.2520   hypothetical protein, conserved
Mus musculus ENSMUSG00000029130   ring finger protein 32
Schmidtea mediterranea mk4.003930.04   RING finger protein 32
Schmidtea mediterranea mk4.000261.17   RING finger protein 32
Trypanosoma brucei gambiense Tbg972.9.8280   hypothetical protein, conserved
Trypanosoma brucei Tb927.9.13300   Ring finger domain containing protein, putative
Trypanosoma cruzi TcCLB.510747.110   Ring finger domain containing protein, putative
Trypanosoma cruzi TcCLB.510657.130   Ring finger domain containing protein, putative
Trichomonas vaginalis TVAG_149530   RING finger protein, putative
Trichomonas vaginalis TVAG_441500   RING finger protein, putative

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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User comments

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Gene identifier Tb927.9.13300 (Trypanosoma brucei), Ring finger domain containing protein, putative
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