Detailed view for ML0875

Basic information

TDR Targets ID: 979709
Mycobacterium leprae, PROBABLE TRANSMEMBRANE CYTOCHROME C OXIDASE (SUBUNIT II) CTAC
Source Database / ID:  Leproma 

pI: 7.4129 | Length (AA): 353 | MW (Da): 39489 | Paralog Number: 0

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 3

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

No Pfam domain information for this protein.

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Metabolic Pathways

Oxidative phosphorylation (KEGG)

Structural information

Modbase 3D models:

There are 5 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
17 83 3d9s (A) 152 226 36.00 0.39 0.02 -0.0050983 2.31
71 315 2yev (B) 46 225 38.00 0 0.65 0.588151 1.45
140 316 4w9z (A) 130 258 32.00 0 0.99 0.486416 0.43
225 301 4f2e (A) 52 123 15.00 0 0.33 0.24213 -0.22
246 304 2iwk (A) 543 595 19.00 0 0.1 0.114139 1.22

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_129173)

Species Accession Gene Product
Arabidopsis thaliana ArthMp015   cytochrome c oxidase subunit 2
Babesia bovis BBOV_IV010440   cytochrome c oxidase subunit 2, putative
Candida albicans CaalfMp01   cytochrome oxidase subunit 2
Echinococcus granulosus EgrG_900000900   cytochrome c oxidase subunit II
Homo sapiens 4513   cytochrome c oxidase subunit II
Loa Loa (eye worm) LOAG_16172   cytochrome oxidase subunit 2
Mycobacterium leprae ML0875   PROBABLE TRANSMEMBRANE CYTOCHROME C OXIDASE (SUBUNIT II) CTAC
Mus musculus 17709   cytochrome c oxidase subunit II
Mycobacterium tuberculosis Rv2200c   Probable transmembrane cytochrome C oxidase (subunit II) CtaC
Mycobacterium ulcerans MUL_3557   transmembrane cytochrome C oxidase (subunit II) CtaC
Neospora caninum NCLIV_054550   Cytochrome c oxidase subunit 2, related
Oryza sativa 6450161   cytochrome c oxidase subunit 2
Onchocerca volvulus OVOC12633   Cytochrome c oxidase subunit 2 homolog
Onchocerca volvulus OVOC7421   Cytochrome c oxidase subunit 2 homolog
Onchocerca volvulus OVOC12867   Cytochrome c oxidase subunit 2 homolog
Onchocerca volvulus OVOC9554  
Onchocerca volvulus OVOC7566   Cytochrome c oxidase subunit 2 homolog
Plasmodium berghei PBANKA_1013800   cytochrome c oxidase subunit 2, putative
Plasmodium falciparum PF3D7_1430900   cytochrome c oxidase subunit 2, putative
Plasmodium knowlesi PKNH_1327800   cytochrome c oxidase subunit 2, putative
Plasmodium vivax PVX_084995   cytochrome c oxidase subunit 2, putative
Plasmodium yoelii PY01261   cytochrome c oxidase subunit II
Saccharomyces cerevisiae Q0250   cytochrome c oxidase subunit 2
Schistosoma japonicum Sjp_0126080   IPR001505,Copper center Cu(A);IPR002429,Cytochrome c oxidase, subunit II;IPR008972,Cupredoxin,domain-containing
Schistosoma japonicum Sjp_0126370   ko:K02275 cytochrome c oxidase subunit II, putative
Schistosoma japonicum Sjp_0126580   IPR001505,Copper center Cu(A);IPR002429,Cytochrome c oxidase, subunit II;IPR008972,Cupredoxin,domain-containing
Schistosoma japonicum Sjp_0017870   Probable cytochrome c oxidase subunit 2, putative
Schistosoma japonicum Sjp_0123730   Cytochrome c oxidase subunit 2, putative
Schistosoma japonicum Sjp_0124200   Probable cytochrome c oxidase subunit 2, putative
Schistosoma japonicum Sjp_0125510   Probable cytochrome c oxidase subunit 2, putative
Schistosoma japonicum Sjp_0124370   Probable cytochrome c oxidase subunit 2, putative
Schistosoma japonicum Sjp_0121160   ko:K02275 cytochrome c oxidase subunit II, putative
Schistosoma japonicum Sjp_0126570   Probable cytochrome c oxidase subunit 2, putative
Schistosoma japonicum Sjp_0123490   Probable cytochrome c oxidase subunit 2, putative
Schistosoma japonicum Sjp_0134540   ko:K02261 cytochrome c oxidase subunit II, putative
Schistosoma japonicum Sjp_0124400   Cytochrome c oxidase subunit 2, putative
Schistosoma japonicum Sjp_0129370   Probable cytochrome c oxidase subunit 2, putative
Schistosoma japonicum Sjp_0124440   Probable cytochrome c oxidase subunit 2, putative
Schistosoma japonicum Sjp_0125870   ko:K02261 cytochrome c oxidase subunit II, putative
Schistosoma japonicum Sjp_0128890   Probable cytochrome c oxidase subunit 2, putative
Schistosoma japonicum Sjp_0129470   IPR001505,Copper center Cu(A);IPR002429,Cytochrome c oxidase, subunit II;IPR008972,Cupredoxin,domain-containing
Schistosoma japonicum Sjp_0130260   ko:K02261 cytochrome c oxidase subunit II, putative
Schistosoma mansoni Smp_095540   cytochrome-c oxidase
Toxoplasma gondii TGME49_310470   cytochrome C oxidase subunit IIb, putative
Theileria parva TP01_0683   cytochrome c oxidase subunit II precursor, putative
Wolbachia endosymbiont of Brugia malayi Wbm0308   cytochrome c oxidase, subunit 2

Essentiality

ML0875 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
PBANKA_1013800 Plasmodium berghei Essential plasmo
TGME49_310470 Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Ovis aries Cytochrome c oxidase subunit 2 Compounds References
Homo sapiens cytochrome c oxidase subunit II Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier ML0875 (Mycobacterium leprae), PROBABLE TRANSMEMBRANE CYTOCHROME C OXIDASE (SUBUNIT II) CTAC
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