Detailed view for ML0283

Basic information

TDR Targets ID: 979946
Mycobacterium leprae, Possible cation-efflux transporter component
Source Database / ID:  Leproma 

pI: 10.9662 | Length (AA): 268 | MW (Da): 29103 | Paralog Number: 0

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 6

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

No Pfam domain information for this protein.

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

No model available for this protein in Modbase.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_127157)

Species Accession Gene Product
Arabidopsis thaliana AT3G61940   zinc transporter (ZAT) family protein
Arabidopsis thaliana AT2G04620   cation efflux family protein
Brugia malayi Bm1_01670   cation efflux family protein
Candida albicans CaO19.10644   likely cation efflux pump similar to S. cerevisiae nuclear cation:cation antiporter MSC2 (YDR205W) involved in zinc ion homeosta
Candida albicans CaO19.3132   likely cation efflux pump similar to S. cerevisiae nuclear cation:cation antiporter MSC2 (YDR205W) involved in zinc ion homeosta
Caenorhabditis elegans CELE_Y105E8A.3   Protein Y105E8A.3
Dictyostelium discoideum DDB_G0291141   cation diffusion facilitator family protein
Drosophila melanogaster Dmel_CG6672   Zinc transporter 86D
Escherichia coli b0752   zinc efflux system
Echinococcus granulosus EgrG_001002800   cation efflux protein: zinc transporter
Echinococcus granulosus EgrG_001068700   zinc transporter 5
Entamoeba histolytica EHI_026390   cation transporter, putative
Echinococcus multilocularis EmuJ_001068700   zinc transporter 5
Echinococcus multilocularis EmuJ_001002800   cation efflux protein: zinc transporter
Homo sapiens ENSG00000164756   solute carrier family 30 (zinc transporter), member 8
Homo sapiens ENSG00000162695   solute carrier family 30 (zinc transporter), member 7
Homo sapiens ENSG00000145740   solute carrier family 30 (zinc transporter), member 5
Leishmania braziliensis LbrM.27.1380   cation transporter, putative
Leishmania donovani LdBPK_271160.1   cation transporter, putative
Leishmania infantum LinJ.27.1160   cation transporter, putative
Leishmania major LmjF.27.1265   cation transporter, putative
Leishmania mexicana LmxM.27.1265   cation transporter, putative
Loa Loa (eye worm) LOAG_09039   hypothetical protein
Mycobacterium leprae ML0283   Possible cation-efflux transporter component
Mus musculus ENSMUSG00000021629   solute carrier family 30 (zinc transporter), member 5
Mus musculus ENSMUSG00000022315   solute carrier family 30 (zinc transporter), member 8
Mus musculus ENSMUSG00000054414   solute carrier family 30 (zinc transporter), member 7
Mycobacterium ulcerans MUL_2837   efflux membrane protein
Oryza sativa 4345598   Os08g0422200
Onchocerca volvulus OVOC1764   Zinc transporter homolog
Saccharomyces cerevisiae YDR205W   metal cation transporter MSC2
Schistosoma japonicum Sjp_0130960   hypothetical protein
Schistosoma japonicum Sjp_0089340   Zinc transporter 5, putative
Schistosoma japonicum Sjp_0089360   similar to Centrosomal protein of 152 kDa, putative
Schistosoma mansoni Smp_170590   cation efflux protein/ zinc transporter
Schmidtea mediterranea mk4.017357.01  
Schmidtea mediterranea mk4.001527.06   Putative cation efflux protein/ zinc transporter
Trypanosoma brucei gambiense Tbg972.11.2040   cation transporter protein, putative
Trypanosoma brucei Tb927.11.1910   cation transporter protein, putative
Trypanosoma brucei Tb427tmp.42.0002   cation transporter protein, putative
Trypanosoma congolense TcIL3000_0_39100   cation transporter protein, putative
Trypanosoma cruzi TcCLB.508357.80   cation transporter protein, putative
Trypanosoma cruzi TcCLB.508355.420   cation transporter protein, putative
Trichomonas vaginalis TVAG_285720   cation efflux protein/ zinc transporter, putative
Trichomonas vaginalis TVAG_132220   cation efflux protein/ zinc transporter, putative
Trichomonas vaginalis TVAG_228020   cation efflux protein/ zinc transporter, putative
Trichomonas vaginalis TVAG_524900   cation efflux protein/ zinc transporter, putative
Wolbachia endosymbiont of Brugia malayi Wbm0383   Co/Zn/Cd efflux system component

Essentiality

ML0283 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb11.42.0002 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb11.42.0002 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (6 days) alsford
Tb11.42.0002 Trypanosoma brucei significant loss of fitness in procyclic forms alsford
Tb11.42.0002 Trypanosoma brucei significant loss of fitness in differentiation of procyclic to bloodstream forms alsford
b0752 Escherichia coli non-essential goodall
Show/Hide essentiality data references
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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User comments

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Gene identifier ML0283 (Mycobacterium leprae), Possible cation-efflux transporter component
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