Detailed view for Rv3352c

Basic information

TDR Targets ID: 980362
Mycobacterium tuberculosis, Possible oxidoreductase
Source Database / ID:  Tuberculist 

pI: 4.6074 | Length (AA): 123 | MW (Da): 12046 | Paralog Number: 2

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF01565  

Gene Ontology

Mouse over links to read term descriptions.
GO:0016614   oxidoreductase activity, acting on CH-OH group of donors  
GO:0050660   FAD binding  
GO:0016491   oxidoreductase activity  
GO:0008762   UDP-N-acetylmuramate dehydrogenase activity  
GO:0003824   catalytic activity  
GO:0055114   oxidation reduction  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 4 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
1 105 3rja (A) 106 210 38.00 0.0000043 1 1.32846 -0.27
1 123 5l6g (A) 129 252 37.00 0.000000048 1 1.3858 0.42
1 107 2y3s (A) 96 207 43.00 0.00000000052 1 1.30672 -0.14
1 107 3vte (A) 149 256 35.00 0.00000012 1 1.29072 -0.13

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_139417)

Species Accession Gene Product
Arabidopsis thaliana AT5G44360   FAD-binding and BBE domain-containing protein
Arabidopsis thaliana AT4G20860   FAD-binding Berberine family protein
Mycobacterium tuberculosis Rv0063   Possible oxidoreductase
Mycobacterium tuberculosis Rv3351c   Conserved hypothetical protein
Mycobacterium tuberculosis Rv3352c   Possible oxidoreductase
Mycobacterium ulcerans MUL_1431   oxidoreductase
Oryza sativa 9271611   Os11g0495950
Oryza sativa 4341259   Os06g0549600
Oryza sativa 4341258   Os06g0549300
Oryza sativa 4341257   Os06g0548800
Oryza sativa 4341254   Os06g0548200
Oryza sativa 4341261   Os06g0549900

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

No user comments are available for this gene. Log in to add comments, or register.

Enter your comment

User ()
Gene identifier Rv3352c (Mycobacterium tuberculosis), Possible oxidoreductase
Title for this comment
Comment