Detailed view for Rv0846c

Basic information

TDR Targets ID: 980908
Mycobacterium tuberculosis, Probable oxidase
Source Database / ID:  Tuberculist 

pI: 6.3183 | Length (AA): 504 | MW (Da): 53796 | Paralog Number: 0

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00394  
PF07731  
PF07732  

Gene Ontology

Mouse over links to read term descriptions.
GO:0016491   oxidoreductase activity  
GO:0005507   copper ion binding  
GO:0055114   oxidation reduction  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 5 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
34 500 3sqr (A) 1 503 26.00 0 1 1.10729 0.1
34 497 3sqr (A) 1 500 31.00 0 1 1.11233 0.2
57 199 5o4i (A) 42 200 38.00 0.000000031 1 0.59043 -0.35
63 242 1sdd (A) 2 245 17.00 0 0.92 0.390843 -0.41
92 154 4bxs (V) 391 462 33.00 0.11 0.99 0.4877 -0.12

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_127196)

Species Accession Gene Product
Arabidopsis thaliana AT4G39830   putative L-ascorbate oxidase
Arabidopsis thaliana AT5G21105   L-ascorbate oxidase
Arabidopsis thaliana AT5G21100   L-ascorbate oxidase
Candida albicans CaO19.8558   similar to S. cerevisiae FET3 (YMR058W) multicopper ferro-O2-oxidoreductase involved in high-affinity iron uptake
Candida albicans CaO19.4211   similar to S. cerevisiae FET3 (YMR058W) multicopper ferro-O2-oxidoreductase involved in high-affinity iron uptake
Candida albicans CaO19.11687   similar to S. cerevisiae FET3 (YMR058W) multicopper ferro-O2-oxidoreductase involved in high-affinity iron uptake
Candida albicans CaO19.11688   similar to S. cerevisiae FET3 (YMR058W) multicopper ferro-O2-oxidoreductase involved in high-affinity iron uptake
Candida albicans CaO19.1206   similar to C terminus of S. cerevisiae FET3 (YMR058W) multicopper oxidase
Candida albicans CaO19.11689   similar to S. cerevisiae FET3 (YMR058W) multicopper ferro-O2-oxidoreductase involved in high-affinity iron uptake
Candida albicans CaO19.4213   similar to S. cerevisiae FET3 (YMR058W) multicopper ferro-O2-oxidoreductase involved in high-affinity iron uptake
Candida albicans CaO19.4215   similar to N terminus of S. cerevisiae FET3 (YMR058W) multicopper ferro-O2-oxidoreductase involved in high-affinity iron uptake
Candida albicans CaO19.8797   similar to C terminus of S. cerevisiae FET3 (YMR058W) multicopper oxidase
Candida albicans CaO19.943   similar to S. cerevisiae FET3 (YMR058W) multicopper ferro-O2-oxidoreductase involved in high-affinity iron uptake
Candida albicans CaO19.11691   similar to N terminus of S. cerevisiae FET3 (YMR058W) multicopper ferro-O2-oxidoreductase involved in high-affinity iron uptake
Candida albicans CaO19.4212   similar to S. cerevisiae FET3 (YMR058W) multicopper ferro-O2-oxidoreductase involved in high-affinity iron uptake
Caenorhabditis elegans CELE_F21D5.3   Protein F21D5.3, isoform C
Drosophila melanogaster Dmel_CG32557   CG32557 gene product from transcript CG32557-RA
Drosophila melanogaster Dmel_CG42345   laccase 2
Drosophila melanogaster Dmel_CG5959   multicopper oxidase 3
Mycobacterium tuberculosis Rv0846c   Probable oxidase
Mycobacterium ulcerans MUL_0341   oxidase
Oryza sativa 4346875   Os09g0365900
Oryza sativa 4341335   Os06g0567200
Oryza sativa 4324803   Os01g0850800
Oryza sativa 4347518   Os09g0507300
Saccharomyces cerevisiae YFL041W   Fet5p
Saccharomyces cerevisiae YMR058W   Fet3p

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Trametes versicolor Laccase Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Rv0846c (Mycobacterium tuberculosis), Probable oxidase
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