Detailed view for Rv3549c

Basic information

TDR Targets ID: 981046
Mycobacterium tuberculosis, Probable short-chain type dehydrogenase/reductase
Source Database / ID:  Tuberculist 

pI: 6.491 | Length (AA): 259 | MW (Da): 26823 | Paralog Number: 0

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

No Pfam domain information for this protein.

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 4 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
11 259 4kzp (A) 17 275 27.00 0 1 1.21049 -0.25
13 76 1lu9 (A) 117 190 23.00 0.024 0.59 0.486204 -1.16
14 249 2d1y (A) 4 248 39.00 0 1 1.4023 -0.57
15 60 3gaz (A) 150 191 43.00 0.92 0.85 0.520706 0.16

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_135645)

Species Accession Gene Product
Homo sapiens ENSG00000115425   peroxisomal trans-2-enoyl-CoA reductase
Mus musculus ENSMUSG00000026189   peroxisomal trans-2-enoyl-CoA reductase
Mycobacterium tuberculosis Rv3549c   Probable short-chain type dehydrogenase/reductase
Mycobacterium ulcerans MUL_4111   short chain dehydrogenase
Oryza sativa 4350416   Os11g0438700

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Staphylococcus aureus (strain NCTC 8325) Enoyl-[acyl-carrier-protein] reductase [NADPH] FabI 256 aa 23.0% 252 aa Compounds References
Bacillus subtilis (strain 168) Enoyl-[acyl-carrier-protein] reductase [NADH] 258 aa 26.5% 260 aa Compounds References
Staphylococcus aureus Enoyl-[acyl-carrier-protein] reductase [NADPH] 256 aa 23.4% 252 aa Compounds References
Staphylococcus aureus Enoyl-ACP reductase 243 aa 23.4% 252 aa Compounds References
Macaca mulatta Hydroxysteroid 11-beta dehydrogenase 1 140 aa 28.2% 142 aa Compounds References
Staphylococcus aureus subsp. aureus MRSA252 Enoyl-[acyl-carrier-protein] reductase 256 aa 23.4% 252 aa Compounds References
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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User comments

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Gene identifier Rv3549c (Mycobacterium tuberculosis), Probable short-chain type dehydrogenase/reductase
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