Detailed view for Rv3480c

Basic information

TDR Targets ID: 981112
Mycobacterium tuberculosis, Possible triacylglycerol synthase (diacylglycerol acyltransferase)
Source Database / ID:  Tuberculist 

pI: 6.5569 | Length (AA): 497 | MW (Da): 53282 | Paralog Number: 12

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF03007  
PF06974  

Gene Ontology

Mouse over links to read term descriptions.
GO:0045017   glycerolipid biosynthetic process  
GO:0004144   diacylglycerol O-acyltransferase activity  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 2 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
5 491 6chj (B) 1 454 38.00 0 1 1.25328 0.07
7 491 6chj (A) 3 454 40.00 0 1 1.19506 0.27

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_133846)

Species Accession Gene Product
Entamoeba histolytica EHI_113590   hypothetical protein
Mycobacterium tuberculosis Rv3734c   Putative triacylglycerol synthase (diacylglycerol acyltransferase) Tgs2
Mycobacterium tuberculosis Rv3740c   Possible triacylglycerol synthase (diacylglycerol acyltransferase)
Mycobacterium tuberculosis Rv3234c   Putative triacylglycerol synthase (diacylglycerol acyltransferase) Tgs3
Mycobacterium tuberculosis Rv3480c   Possible triacylglycerol synthase (diacylglycerol acyltransferase)
Mycobacterium tuberculosis Rv3371   Possible triacylglycerol synthase (diacylglycerol acyltransferase)
Mycobacterium tuberculosis Rv0895   Possible triacylglycerol synthase (diacylglycerol acyltransferase)
Mycobacterium tuberculosis Rv2285   Possible triacylglycerol synthase (diacylglycerol acyltransferase)
Mycobacterium tuberculosis Rv1760   Possible triacylglycerol synthase (diacylglycerol acyltransferase)
Mycobacterium tuberculosis Rv0221   Possible triacylglycerol synthase (diacylglycerol acyltransferase)
Mycobacterium tuberculosis Rv3087   Possible triacylglycerol synthase (diacylglycerol acyltransferase)
Mycobacterium tuberculosis Rv3088   Putative triacylglycerol synthase (diacylglycerol acyltransferase) Tgs4
Mycobacterium tuberculosis Rv3130c   Triacylglycerol synthase (diacylglycerol acyltransferase) Tgs1
Mycobacterium tuberculosis Rv1425   Possible triacylglycerol synthase (diacylglycerol acyltransferase)
Mycobacterium ulcerans MUL_2706   hypothetical protein
Mycobacterium ulcerans MUL_2057   hypothetical protein
Mycobacterium ulcerans MUL_2420   hypothetical protein
Mycobacterium ulcerans MUL_3161   hypothetical protein
Mycobacterium ulcerans MUL_3271   hypothetical protein
Mycobacterium ulcerans MUL_1193   hypothetical protein
Mycobacterium ulcerans MUL_1313   hypothetical protein
Mycobacterium ulcerans MUL_1818   hypothetical protein
Mycobacterium ulcerans MUL_3162   hypothetical protein
Mycobacterium ulcerans MUL_4351   hypothetical protein

Essentiality

Rv3480c has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
mtu1448 Mycobacterium tuberculosis non-essential nmpdr
mtu1790 Mycobacterium tuberculosis non-essential nmpdr
mtu3140 Mycobacterium tuberculosis non-essential nmpdr
mtu3141 Mycobacterium tuberculosis non-essential nmpdr
mtu3431 Mycobacterium tuberculosis non-essential nmpdr
mtu3799 Mycobacterium tuberculosis non-essential nmpdr
mtu3805 Mycobacterium tuberculosis non-essential nmpdr
Show/Hide essentiality data references
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

No user comments are available for this gene. Log in to add comments, or register.

Enter your comment

User ()
Gene identifier Rv3480c (Mycobacterium tuberculosis), Possible triacylglycerol synthase (diacylglycerol acyltransferase)
Title for this comment
Comment