Detailed view for Rv2056c

Basic information

TDR Targets ID: 981162
Mycobacterium tuberculosis, 30S ribosomal protein S14 RpsN2
Source Database / ID:  Tuberculist 

pI: 12.6844 | Length (AA): 101 | MW (Da): 11409 | Paralog Number: 1

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00253  

Gene Ontology

Mouse over links to read term descriptions.
GO:0005840   ribosome  
GO:0005622   intracellular  
GO:0003735   structural constituent of ribosome  
GO:0006412   translation  

Metabolic Pathways

Ribosome (KEGG)

Structural information

Modbase 3D models:

There are 2 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
41 101 2vqe (N) 3 61 47.00 0 0.78 1.11646 -0.2
44 101 2vqe (N) 2 61 47.00 0.00000003 0.82 1.10286 -0.15

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_127575)

Species Accession Gene Product
Arabidopsis thaliana ArthCp020   30S ribosomal protein S14
Arabidopsis thaliana AT2G34520   small subunit ribosomal protein S14
Babesia bovis BBOV_I000700   ribosomal protein S14p/S29e domain containing protein
Brugia malayi Bm1_14960   40S ribosomal protein S14, mitochondrial
Candida albicans CaO19.4023   likely mitochondrial ribosomal protein similar to S. cerevisiae MRP2 (YPR166C) small subunit protein (E. coli S14)
Candida albicans CaO19.11506   likely mitochondrial ribosomal protein similar to S. cerevisiae MRP2 (YPR166C) small subunit protein (E. coli S14)
Caenorhabditis elegans CELE_T01E8.6   Protein MRPS-14
Chlamydia trachomatis CT_787   30S ribosomal protein S14
Dictyostelium discoideum DidioMp31   ribosomal protein S14
Drosophila melanogaster Dmel_CG32531   mitochondrial ribosomal protein S14
Escherichia coli b3307   30S ribosomal subunit protein S14
Echinococcus granulosus EgrG_000147000   28S ribosomal protein S14 mitochondrial
Echinococcus multilocularis EmuJ_000147000   28S ribosomal protein S14, mitochondrial
Echinococcus multilocularis EmuJ_000137100   28S ribosomal protein S14, mitochondrial
Homo sapiens ENSG00000120333   mitochondrial ribosomal protein S14
Mycobacterium leprae ML1846c   PROBABLE 30S RIBOSOMAL PROTEIN S14 RPSN
Mus musculus 64659   mitochondrial ribosomal protein S14
Mycobacterium tuberculosis Rv0717   30S ribosomal protein S14 RpsN1
Mycobacterium tuberculosis Rv2056c   30S ribosomal protein S14 RpsN2
Mycobacterium ulcerans MUL_4833   30S ribosomal protein S14
Mycobacterium ulcerans MUL_0807   30S ribosomal protein S14
Oryza sativa 3131436   30S ribosomal protein S14
Plasmodium berghei PBANKA_0911200   apicoplast ribosomal protein S14p/S29e precursor, putative
Plasmodium falciparum PF3D7_1137500   apicoplast ribosomal protein S14p/S29e precursor, putative
Plasmodium knowlesi PKNH_0935700   30S ribosomal protein S14, putative
Plasmodium yoelii PY02435   ribosomal protein S14p/S29e, putative
Saccharomyces cerevisiae YPR166C   mitochondrial 37S ribosomal protein MRP2
Schistosoma japonicum Sjp_0218250   ko:K02954 small subunit ribosomal protein S14, putative
Schistosoma mansoni Smp_090920.3   mitochondrial 28S ribosomal protein S14 (s14mt)
Schmidtea mediterranea mk4.006635.00   Probable 40S ribosomal protein S14, mitochondrial
Toxoplasma gondii TGME49_286610   ribosomal protein RPS14, putative
Treponema pallidum TP0202   30S ribosomal protein S14
Theileria parva TP02_0867   hypothetical protein
Wolbachia endosymbiont of Brugia malayi Wbm0328   30S ribosomal protein S14

Essentiality

Rv2056c has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
b3307 Escherichia coli essential goodall
CELE_T01E8.6 Caenorhabditis elegans embryonic lethal wormbase
CELE_T01E8.6 Caenorhabditis elegans larval arrest wormbase
CELE_T01E8.6 Caenorhabditis elegans slow growth wormbase
CELE_T01E8.6 Caenorhabditis elegans sterile wormbase
PBANKA_0911200 Plasmodium berghei Essential plasmo
TGME49_286610 Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Rv2056c (Mycobacterium tuberculosis), 30S ribosomal protein S14 RpsN2
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