Detailed view for OVOC4115

Basic information

TDR Targets ID: 982022
Onchocerca volvulus, UPF0553 protein C9orf64 homolog
Source Database / ID:  Wormbase Parasite  

pI: 9.1525 | Length (AA): 643 | MW (Da): 70909 | Paralog Number: 0

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 1

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF10343  

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

No model available for this protein in Modbase.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_130329)

Species Accession Gene Product
Brugia malayi Bm1_25255   hypothetical protein
Caenorhabditis elegans CELE_C11D2.4   Protein C11D2.4
Dictyostelium discoideum DDB_G0288723   UPF0553 family protein
Drosophila melanogaster Dmel_CG9752   CG9752 gene product from transcript CG9752-RA
Echinococcus granulosus EgrG_000099000   protein of unknown function DUF2419
Entamoeba histolytica EHI_098190   hypothetical protein
Echinococcus multilocularis EmuJ_000099000   protein of unknown function DUF2419
Homo sapiens ENSG00000165118   chromosome 9 open reading frame 64
Loa Loa (eye worm) LOAG_11695   hypothetical protein
Mus musculus ENSMUSG00000021550   RIKEN cDNA 2210016F16 gene
Oryza sativa 4343766   Os07g0588800
Onchocerca volvulus OVOC4115   UPF0553 protein C9orf64 homolog
Schistosoma japonicum Sjp_0115770   similar to UPF0553 protein C589.05c, putative
Schistosoma mansoni Smp_094920   hypothetical protein
Schmidtea mediterranea mk4.000013.23   UPF0553 protein C9orf64
Trichomonas vaginalis TVAG_489760   spac589.05C protein, putative

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Lolium rigidum Acetolactate synthase 516 aa 25.4% 496 aa Compounds References
Raphanus raphanistrum Acetolactate synthase 604 aa 25.3% 534 aa Compounds References
Bromus tectorum Acetolactate synthase 583 aa 24.8% 541 aa Compounds References
Zea mays Acetolactate synthase 638 aa 25.0% 536 aa Compounds References
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier OVOC4115 (Onchocerca volvulus), UPF0553 protein C9orf64 homolog
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