Detailed view for OVOC9259

Basic information

TDR Targets ID: 982078
Onchocerca volvulus,
Source Database / ID:  Wormbase Parasite  

pI: 7.5431 | Length (AA): 283 | MW (Da): 32339 | Paralog Number: 8169

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

No Pfam domain information for this protein.

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

No model available for this protein in Modbase.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

This protein does not belong to any OrthoMCL cluster.

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Canis lupus familiaris Tryptase 275 aa 27.9% 269 aa Compounds References
Rattus norvegicus Tryptase alpha/beta-1 273 aa 26.1% 272 aa Compounds References
Sus scrofa Elastase 1 266 aa 26.7% 266 aa Compounds References
Oryctolagus cuniculus Thrombin 235 aa 25.8% 225 aa Compounds References
Sus scrofa Pancreatic elastase 269 aa 26.5% 260 aa Compounds References
Rattus norvegicus Trypsin II 246 aa 25.8% 256 aa Compounds References
Bos taurus Trypsin I 246 aa 22.2% 266 aa Compounds References
Rattus norvegicus Anionic trypsin-1 246 aa 26.4% 254 aa Compounds References
Sus scrofa Glandular kallikrein 246 aa 22.1% 276 aa Compounds References
Rattus norvegicus Elastase 2A 271 aa 26.4% 265 aa Compounds References
Sus scrofa Elastase 2A 269 aa 26.5% 260 aa Compounds References
Bos taurus Alpha-chymotrypsin 245 aa 27.5% 240 aa Compounds References
Canis lupus familiaris Coagulation factor X 159 aa 22.6% 190 aa Compounds References
Bos taurus Beta-chymotrypsin 245 aa 28.7% 237 aa Compounds References
Bos taurus Trypsin II 247 aa 26.5% 257 aa Compounds References
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

No user comments are available for this gene. Log in to add comments, or register.

Enter your comment

User ()
Gene identifier OVOC9259 (Onchocerca volvulus),
Title for this comment
Comment