Detailed view for OVOC6733

Basic information

TDR Targets ID: 983520
Onchocerca volvulus,
Source Database / ID:  Wormbase Parasite  

pI: 10.8269 | Length (AA): 86 | MW (Da): 10199 | Paralog Number: 0

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00023  
PF03399  
PF12796  

Gene Ontology

Mouse over links to read term descriptions.
GO:0005852   eukaryotic translation initiation factor 3 complex  
GO:0005737   cytoplasm  
GO:0043022   ribosome binding  
GO:0005515   protein binding  
GO:0005488   binding  
GO:0003743   translation initiation factor activity  
GO:0006446   regulation of translational initiation  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 13 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
1 48 2zgd (A) 42 85 12.00 0.00057 0.25 0.112634 -0.45
1 333 5y4f (A) 448 788 18.00 0.000000019 1 0.465149 -0.06
24 203 4g8k (A) 28 194 35.00 0.00000013 0.91 0.332178 0.59
48 206 2f8y (A) 1919 2090 30.00 0.00000000091 1 0.45375 -0.71
60 222 5le9 (A) 112 279 31.00 0.000000004 1 0.61307 -1.27
92 260 5iwk (A) 90 298 33.00 0.039 1 0.316049 -0.05
143 211 4hi8 (A) 32 100 38.00 0.000032 1 0.724061 -1.96
147 208 3c5r (A) 463 524 44.00 0.000028 1 0.740252 -1.58
147 214 1ycs (B) 329 396 26.00 0 0.96 0.525832 -1.4
178 215 5d66 (A) 41 78 21.00 0 0.89 0.389935 -0.86
180 215 5aq7 (A) 16 51 33.00 0 1 0.499276 -0.66
965 1191 1rz4 (A) 2 210 36.00 0 1 0.648182 -0.99
1116 1176 4d10 (H) 111 196 13.00 1 0.26 0.290422 -1.01

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_156119)

Species Accession Gene Product
Brugia malayi Bm1_52950   hypothetical protein
Caenorhabditis elegans CELE_T16G1.9   Protein T16G1.9
Loa Loa (eye worm) LOAG_05646   hypothetical protein
Onchocerca volvulus OVOC6733  

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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