Detailed view for OVOC1706

Basic information

TDR Targets ID: 983521
Onchocerca volvulus,
Source Database / ID:  Wormbase Parasite  

pI: 5.0813 | Length (AA): 268 | MW (Da): 30691 | Paralog Number: 0

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF06212  

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Structural information

Modbase 3D models:

No model available for this protein in Modbase.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_129943)

Species Accession Gene Product
Arabidopsis thaliana AT1G04630   NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13-A
Arabidopsis thaliana AT2G33220   NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13-B
Brugia malayi Bm1_18845   GRIM-19 protein
Caenorhabditis elegans CELE_C34B2.8   Protein C34B2.8
Dictyostelium discoideum DDB_G0274311   GRIM-19 domain-containing protein
Drosophila melanogaster Dmel_CG3446   CG3446 gene product from transcript CG3446-RA
Homo sapiens 51079   NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 13
Loa Loa (eye worm) LOAG_04830   hypothetical protein
Mus musculus ENSMUSG00000036199   NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 13
Oryza sativa 4331914   Os03g0192400
Onchocerca volvulus OVOC1706  
Schistosoma japonicum Sjp_0035200   ko:K00356 NADH dehydrogenase [EC1.6.99.3], putative
Schistosoma mansoni Smp_004550.1   hypothetical protein
Schmidtea mediterranea mk4.000917.00  

Essentiality

OVOC1706 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_C34B2.8 Caenorhabditis elegans embryonic lethal wormbase
CELE_C34B2.8 Caenorhabditis elegans larval arrest wormbase
CELE_C34B2.8 Caenorhabditis elegans slow growth wormbase
CELE_C34B2.8 Caenorhabditis elegans sterile wormbase
Show/Hide essentiality data references
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 13 Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0336 0.2666 0.4988
0.0336 0.2666 0.4988

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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User comments

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Gene identifier OVOC1706 (Onchocerca volvulus),
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