Detailed view for OVOC471

Basic information

TDR Targets ID: 983750
Onchocerca volvulus, Ceramide kinase 1 homolog
Source Database / ID:  Wormbase Parasite  

pI: 4.6581 | Length (AA): 93 | MW (Da): 10802 | Paralog Number: 0

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00781  

Gene Ontology

Mouse over links to read term descriptions.
GO:0004143   diacylglycerol kinase activity  
GO:0003951   NAD+ kinase activity  
GO:0008152   metabolic process  
GO:0007205   activation of protein kinase C activity  

Metabolic Pathways

Sphingolipid metabolism (KEGG)

Structural information

Modbase 3D models:

There are 3 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
167 315 2qv7 (A) 0 125 28.00 0.095 1 0.434632 -0.03
191 264 2r3v (A) 85 170 36.00 0.17 0.3 0.24565 1.06
437 524 2hf2 (A) 173 263 28.00 0.42 0.27 0.300913 0.72

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_132239)

Species Accession Gene Product
Arabidopsis thaliana AT5G51290   ceramide kinase
Brugia malayi Bm1_50005   Ceramide kinase
Caenorhabditis elegans CELE_T10B11.2   Protein T10B11.2
Drosophila melanogaster Dmel_CG16708   Ceramide kinase
Echinococcus granulosus EgrG_000868200   ceramide kinase
Echinococcus multilocularis EmuJ_000868200   ceramide kinase
Homo sapiens ENSG00000100422   ceramide kinase
Loa Loa (eye worm) LOAG_11245   ceramide kinase
Mus musculus ENSMUSG00000035891   ceramide kinase
Oryza sativa 4330198   Os02g0656200
Onchocerca volvulus OVOC471   Ceramide kinase 1 homolog
Schmidtea mediterranea mk4.005701.02  
Schmidtea mediterranea mk4.005701.00   Ceramide kinase 1

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens ceramide kinase Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier OVOC471 (Onchocerca volvulus), Ceramide kinase 1 homolog
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