Detailed view for Rv3876

Basic information

TDR Targets ID: 9838
Mycobacterium tuberculosis, ESX-1 secretion-associated protein EspI. Conserved proline and alanine rich protein.
Source Database / ID:  Tuberculist 

pI: 10.2742 | Length (AA): 666 | MW (Da): 70645 | Paralog Number: 0

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF01656   CobQ/CobB/MinD/ParA nucleotide binding domain

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 8 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
105 135 5ctd (B) 2 35 55.00 0.3 0.07 0.606347 -1.71
386 583 3la6 (A) 494 689 16.00 0.0000021 0.7 0.524997 -0.52
412 656 5j1j (A) 6 250 20.00 0 1 0.612568 -0.19
416 656 1g3q (A) 2 233 22.00 0 1 0.665562 -0.68
418 631 1wcv (1) 8 213 25.00 0 1 0.535921 -0.48
419 656 3ea0 (A) 4 239 17.00 0 1 0.548957 -0.66
419 478 1hyq (A) 5 64 45.00 0.019 0.2 0.43289 0.89
419 558 1ion (A) 5 140 32.00 0.0036 0.33 0.25401 0.21

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Upper 80-100% percentile Dormant phase. hasan
Upregulation Percent Ranking Stage Dataset
Lower 20-40% percentile Dormant phase. murphy
Show/Hide expression data references
  • hasan Prioritizing genomic drug targets in pathogens: application to Mycobacterium tuberculosis.
  • murphy Identification of gene targets against dormant phase Mycobacterium tuberculosis infections.

Orthologs

Ortholog group members (OG5_152910)

Species Accession Gene Product
Caenorhabditis elegans CELE_Y40C5A.3   Protein Y40C5A.3, isoform A
Mycobacterium leprae ML0048c   Conserved hypothetical proline and alanine rich protein
Mycobacterium tuberculosis Rv3876   ESX-1 secretion-associated protein EspI. Conserved proline and alanine rich protein.
Treponema pallidum TP0369   hypothetical protein

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Druggability index (range: 0 to 1): 0.5

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Rv3876 (Mycobacterium tuberculosis), ESX-1 secretion-associated protein EspI. Conserved proline and alanine rich protein.
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