Detailed view for OVOC833

Basic information

TDR Targets ID: 984493
Onchocerca volvulus, Abnormal oocyte homolog
Source Database / ID:  Wormbase Parasite  

pI: 8.3808 | Length (AA): 395 | MW (Da): 45693 | Paralog Number: 0

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF09737  

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

No model available for this protein in Modbase.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_132401)

Species Accession Gene Product
Arabidopsis thaliana AT4G10180   light-mediated development protein DET1
Brugia malayi Bm1_49185   DET1 homolog
Dictyostelium discoideum DDB_G0277075   hypothetical protein
Drosophila melanogaster Dmel_CG6093   abnormal oocyte
Homo sapiens ENSG00000140543   de-etiolated homolog 1 (Arabidopsis)
Loa Loa (eye worm) LOAG_06916   hypothetical protein
Loa Loa (eye worm) LOAG_06561   hypothetical protein
Mus musculus ENSMUSG00000030610   de-etiolated homolog 1 (Arabidopsis)
Oryza sativa 4326296   Os01g0104600
Onchocerca volvulus OVOC833   Abnormal oocyte homolog

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Sus scrofa Casein kinase I isoform alpha 125 aa 33.1% 139 aa Compounds References
Bos taurus Casein kinase I isoform alpha 325 aa 28.5% 316 aa Compounds References
Plasmodium falciparum (isolate 3D7) Cell division control protein 2 homolog 288 aa 24.1% 232 aa Compounds References
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier OVOC833 (Onchocerca volvulus), Abnormal oocyte homolog
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