Detailed view for OVOC12576

Basic information

TDR Targets ID: 984588
Onchocerca volvulus,
Source Database / ID:  Wormbase Parasite  

pI: 9.367 | Length (AA): 355 | MW (Da): 41160 | Paralog Number: 0

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 8

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00595  

Gene Ontology

Mouse over links to read term descriptions.
GO:0005515   protein binding  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 4 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
181 457 5v6b (A) 49 327 45.00 0 1 0.955799 0.61
259 353 3gge (A) 0 203 50.00 0 1 0.861987 -1.02
287 344 2rcz (A) 205 261 19.00 0.11 0.48 0.328383 -0.07
385 460 5v6h (A) 238 312 32.00 0 1 0.75065 -2.1

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_130355)

Species Accession Gene Product
Brugia malayi Bm1_22655   hypothetical protein
Brugia malayi Bm1_23845   hypothetical protein
Caenorhabditis elegans CELE_F44D12.4   Protein GIPC-2
Caenorhabditis elegans CELE_C35D10.2   Protein GIPC-1
Drosophila melanogaster Dmel_CG11546   CG11546 gene product from transcript CG11546-RB
Echinococcus granulosus EgrG_000190700   PDZ domain containing protein GIPC3
Echinococcus multilocularis EmuJ_000007800   PDZ domain containing protein GIPC3
Echinococcus multilocularis EmuJ_000190700   PDZ domain containing protein GIPC3
Homo sapiens 54810   GIPC PDZ domain containing family, member 2
Homo sapiens ENSG00000123159   GIPC PDZ domain containing family, member 1
Homo sapiens ENSG00000179855   GIPC PDZ domain containing family, member 3
Loa Loa (eye worm) LOAG_13156   hypothetical protein
Mus musculus ENSMUSG00000019433   GIPC PDZ domain containing family, member 1
Mus musculus 54120   GIPC PDZ domain containing family, member 2
Mus musculus ENSMUSG00000034872   GIPC PDZ domain containing family, member 3
Onchocerca volvulus OVOC12576  
Schistosoma japonicum Sjp_0023230   similar to Centrosomal protein of 164 kDa, putative
Schistosoma japonicum Sjp_0023190   PDZ domain-containing protein GIPC3, putative
Schistosoma japonicum Sjp_0023200   Receptor-type tyrosine-protein phosphatase eta precursor, putative
Schistosoma mansoni Smp_170870   rgs-gaip interacting protein gipc
Schmidtea mediterranea mk4.000571.01  

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier OVOC12576 (Onchocerca volvulus),
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