Detailed view for OVOC4137

Basic information

TDR Targets ID: 984787
Onchocerca volvulus,
Source Database / ID:  Wormbase Parasite  

pI: 4.6593 | Length (AA): 454 | MW (Da): 51331 | Paralog Number: 0

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF08241  

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 4 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
70 183 1inl (D) 76 212 21.00 0 0.09 0.396058 0.04
71 177 1xtp (A) 80 197 21.00 0 0.65 0.582511 -0.52
74 228 4obx (A) 101 286 16.00 0.00016 0.94 0.575693 0.36
87 171 1xxl (A) 15 109 38.00 0.00032 0.63 0.431719 0.13

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_149693)

Species Accession Gene Product
Brugia malayi Bm1_36355   hypothetical protein
Caenorhabditis elegans CELE_F49C12.10   Protein F49C12.10
Cryptosporidium hominis Chro.80382   methyltransferase
Cryptosporidium parvum cgd8_3290   secreted bacterial type DHHB/UbiG like methyltransferase involved in ubiquinone/menaquinone biosynthesis, signal peptide
Loa Loa (eye worm) LOAG_02551   hypothetical protein
Mycobacterium leprae ML0130c   Probable methyltransferase (Methylase)
Mycobacterium tuberculosis Rv2952   Possible methyltransferase (methylase)
Mycobacterium ulcerans MUL_2377   methyltransferase
Mycobacterium ulcerans MUL_2009   methyltransferase
Onchocerca volvulus OVOC4137  

Essentiality

OVOC4137 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
mtu3001 Mycobacterium tuberculosis non-essential nmpdr
Show/Hide essentiality data references
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Leishmania donovani Beta tubulin 43 aa 72.1% 43 aa Compounds References
Rattus norvegicus Tubulin alpha-1 chain 451 aa 41.5% 434 aa Compounds References
Bos taurus Tubulin 85 aa 50.0% 80 aa Compounds References
Bos taurus Tubulin 445 aa 82.4% 427 aa Compounds References
Bos taurus Tubulin beta chain 445 aa 82.4% 427 aa Compounds References
Ovis aries Tubulin alpha 4a 448 aa 40.7% 447 aa Compounds References
Sus scrofa Tubulin 445 aa 82.7% 427 aa Compounds References
Sus scrofa Tubulin alpha chain 451 aa 41.5% 434 aa Compounds References
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier OVOC4137 (Onchocerca volvulus),
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