Detailed view for OVOC4038

Basic information

TDR Targets ID: 984861
Onchocerca volvulus,
Source Database / ID:  Wormbase Parasite  

pI: 9.8425 | Length (AA): 429 | MW (Da): 48920 | Paralog Number: 8169

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 7

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

No Pfam domain information for this protein.

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 5 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
1 831 4fgv (A) 5 854 10.00 0 0.92 1.00811 0.27
2 822 4c0p (A) 31 918 11.00 0 1 0.951385 0.37
154 381 4tql (A) 9 236 7.00 0.058 0.08 0.409992 -0.91
162 345 4uos (A) 3 184 14.00 0.75 0.33 0.499409 -1.47
517 684 1o6v (A) 112 289 29.00 0.93 0.52 0.313952 0.78

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

This protein does not belong to any OrthoMCL cluster.

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Rattus norvegicus Neurotensin receptor 1 424 aa 21.4% 457 aa Compounds References
Cavia porcellus Mu opioid receptor 98 aa 32.2% 87 aa Compounds References
Sus scrofa Serotonin 1d (5-HT1d) receptor 291 aa 36.1% 313 aa Compounds References
Canis lupus familiaris Beta-3 adrenergic receptor 405 aa 29.1% 344 aa Compounds References
Rattus norvegicus Trace amine-associated receptor 1 332 aa 27.6% 362 aa Compounds References
Rattus norvegicus Serotonin 1 (5-HT1) receptor 366 aa 33.1% 357 aa Compounds References
Rattus norvegicus Histamine H4 receptor 391 aa 25.4% 362 aa Compounds References
Rattus norvegicus Serotonin 1b (5-HT1b) receptor 386 aa 34.0% 338 aa Compounds References
Rattus norvegicus Serotonin 5b (5-HT5b) receptor 370 aa 34.3% 344 aa Compounds References
Cavia porcellus Serotonin 4 (5-HT4) receptor 388 aa 30.8% 367 aa Compounds References
Rattus norvegicus Trace amine-associated receptor 7b 358 aa 26.4% 398 aa Compounds References
Rattus norvegicus Vasopressin receptor 425 aa 21.9% 392 aa Compounds References
Macaca mulatta Beta-3 adrenergic receptor 418 aa 28.9% 350 aa Compounds References
Cricetulus griseus 5-hydroxytryptamine receptor 422 aa 33.8% 394 aa Compounds References
Gorilla gorilla Serotonin 1b (5-HT1b) receptor 390 aa 33.3% 360 aa Compounds References
Rattus norvegicus Serotonin 1B/1D receptor 374 aa 33.9% 386 aa Compounds References
Rattus norvegicus Vasopressin V1 receptor 425 aa 21.9% 392 aa Compounds References
Rattus norvegicus Dopamine D4 receptor 387 aa 34.1% 346 aa Compounds References
Cricetulus griseus 5-hydroxytryptamine receptor 1B 386 aa 34.7% 337 aa Compounds References
Rattus norvegicus Beta-2 adrenergic receptor 418 aa 28.1% 352 aa Compounds References
Rattus norvegicus Neurotensin receptor 2 416 aa 21.7% 373 aa Compounds References
Canis lupus familiaris Beta-2 adrenergic receptor 415 aa 27.0% 385 aa Compounds References
Rattus norvegicus Orexin receptor 1 416 aa 25.3% 364 aa Compounds References
Bos taurus Beta-2 adrenergic receptor 418 aa 28.1% 352 aa Compounds References
Carassius auratus Dopamine D1 receptor 363 aa 32.2% 367 aa Compounds References
Sus scrofa Serotonin 4 (5-HT4) receptor 402 aa 30.0% 390 aa Compounds References
Rattus norvegicus Thyrotropin-releasing hormone receptor 2 352 aa 23.0% 352 aa Compounds References
Rattus norvegicus Serotonin 5a (5-HT5a) receptor 357 aa 33.1% 338 aa Compounds References
Chlorocebus aethiops Dopamine D3 receptor 400 aa 32.7% 370 aa Compounds References
Rattus norvegicus Serotonin 1d (5-HT1d) receptor 374 aa 33.9% 386 aa Compounds References
Rattus norvegicus Vasopressin V1b receptor 425 aa 21.9% 392 aa Compounds References
Cavia porcellus Histamine H4 receptor 389 aa 26.6% 364 aa Compounds References
Cavia porcellus Serotonin 1d (5-HT1d) receptor 376 aa 35.5% 352 aa Compounds References
Mesocricetus auratus Beta-2 adrenergic receptor 418 aa 29.3% 352 aa Compounds References
Cavia porcellus Beta-2 adrenergic receptor 418 aa 28.1% 352 aa Compounds References
Macaca mulatta Trace amine-associated receptor 1 338 aa 27.3% 362 aa Compounds References
Rattus norvegicus Serotonin 4 (5-HT4) receptor 406 aa 30.5% 387 aa Compounds References
Rattus norvegicus Serotonin (5-HT) receptor 386 aa 34.0% 338 aa Compounds References
Rattus norvegicus Serotonin 1a (5-HT1a) receptor 422 aa 33.6% 390 aa Compounds References
Rattus norvegicus Serotonin 1f (5-HT1f) receptor 366 aa 33.1% 357 aa Compounds References
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier OVOC4038 (Onchocerca volvulus),
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