Detailed view for OVOC3826

Basic information

TDR Targets ID: 985761
Onchocerca volvulus,
Source Database / ID:  Wormbase Parasite  

pI: 8.5695 | Length (AA): 375 | MW (Da): 42337 | Paralog Number: 8169

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 7

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

No Pfam domain information for this protein.

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 2 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
6 64 2l9j (A) 103 163 22.00 0 0.15 1.15999 -0.73
25 58 1tbu (A) 73 106 32.00 0.79 0.03 0.774377 0.62

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

This protein does not belong to any OrthoMCL cluster.

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Rattus norvegicus Adenosine A3 receptor 320 aa 24.9% 350 aa Compounds References
Gallus gallus Melatonin receptor 346 aa 22.4% 343 aa Compounds References
Canis lupus familiaris Uncharacterized protein 335 aa 21.3% 310 aa Compounds References
Rattus norvegicus Gonadotropin-releasing hormone receptor 327 aa 19.5% 292 aa Compounds References
Rattus norvegicus Trace amine-associated receptor 1 332 aa 29.3% 345 aa Compounds References
Rattus norvegicus Histamine H2 receptor 358 aa 32.3% 341 aa Compounds References
Macaca mulatta Gonadotropin-releasing hormone receptor 59 aa 24.5% 49 aa Compounds References
Bos taurus Rhodopsin 348 aa 20.9% 321 aa Compounds References
Rattus norvegicus Serotonin 1 (5-HT1) receptor 366 aa 30.9% 356 aa Compounds References
Rattus norvegicus Serotonin 5b (5-HT5b) receptor 370 aa 29.9% 334 aa Compounds References
Bos taurus 5-hydroxytryptamine 1D receptor 119 aa 45.1% 102 aa Compounds References
Sus scrofa Serotonin 1d (5-HT1d) receptor 291 aa 33.9% 319 aa Compounds References
Macaca fascicularis Melanin-concentrating hormone receptor 1 249 aa 22.7% 299 aa Compounds References
Bos taurus Adenosine receptor A3 317 aa 23.5% 345 aa Compounds References
Cavia porcellus Histamine H2 receptor 359 aa 32.1% 330 aa Compounds References
Rattus norvegicus Melanocortin receptor 3 323 aa 24.7% 360 aa Compounds References
Macaca mulatta Trace amine-associated receptor 1 338 aa 30.1% 349 aa Compounds References
Rattus norvegicus Adenosine A2b receptor 332 aa 29.4% 361 aa Compounds References
Rattus norvegicus Serotonin 1B/1D receptor 374 aa 33.4% 362 aa Compounds References
Rattus norvegicus Free fatty acid receptor 4 361 aa 22.9% 314 aa Compounds References
Rattus norvegicus G protein-coupled receptor 80 337 aa 22.1% 353 aa Compounds References
Rattus norvegicus Ghrelin receptor 364 aa 23.9% 343 aa Compounds References
Canis familiaris Chemokine (C-C motif) receptor 1 354 aa 21.1% 346 aa Compounds References
Rattus norvegicus Melanocortin receptor 5 325 aa 22.9% 354 aa Compounds References
Carassius auratus Dopamine D1 receptor 363 aa 37.5% 352 aa Compounds References
Rattus norvegicus Melatonin receptor 1B 364 aa 22.9% 340 aa Compounds References
Bos taurus Vasopressin V2 receptor 370 aa 22.4% 321 aa Compounds References
Macaca fascicularis G-protein coupled receptor 119 335 aa 24.0% 350 aa Compounds References
Rattus norvegicus Lysophosphatidic acid receptor Edg-2 364 aa 22.5% 355 aa Compounds References
Rattus norvegicus Vasopressin V2 receptor 371 aa 21.4% 331 aa Compounds References
Gallus gallus Melatonin receptor 1B 289 aa 21.2% 321 aa Compounds References
Rattus norvegicus Serotonin 1f (5-HT1f) receptor 366 aa 30.9% 356 aa Compounds References
Rattus norvegicus Melanin-concentrating hormone receptor 1 360 aa 22.9% 340 aa Compounds References
Rattus norvegicus Thyrotropin-releasing hormone receptor 2 352 aa 24.3% 338 aa Compounds References
Rattus norvegicus Trace amine-associated receptor 7b 358 aa 27.9% 348 aa Compounds References
Gallus gallus Adenosine A1 receptor 324 aa 25.6% 347 aa Compounds References
Oryctolagus cuniculus Adenosine A3 receptor 319 aa 23.2% 358 aa Compounds References
Canis lupus familiaris Adenosine receptor A3 314 aa 24.1% 349 aa Compounds References
Rattus norvegicus Serotonin 1d (5-HT1d) receptor 374 aa 33.4% 362 aa Compounds References
Rattus norvegicus Melanocortin receptor 4 332 aa 23.0% 352 aa Compounds References
Oryctolagus cuniculus Growth hormone secretagogue receptor type 1 366 aa 24.9% 345 aa Compounds References
Rattus norvegicus Adenosine receptor 332 aa 29.4% 361 aa Compounds References
Rattus norvegicus Serotonin 5a (5-HT5a) receptor 357 aa 30.3% 347 aa Compounds References
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier OVOC3826 (Onchocerca volvulus),
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