Detailed view for OVOC2304

Basic information

TDR Targets ID: 986191
Onchocerca volvulus,
Source Database / ID:  Wormbase Parasite  

pI: 9.7745 | Length (AA): 341 | MW (Da): 38931 | Paralog Number: 0

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 2

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00622  

Gene Ontology

Mouse over links to read term descriptions.
GO:0005515   protein binding  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 4 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
32 173 2ihs (A) 48 222 15.00 0 0.99 0.703568 0.24
35 194 4xw3 (A) 89 258 16.00 0.0025 0.93 1.02352 -0.57
36 192 3toj (A) 286 496 15.00 0 0.87 0.946195 -0.42
61 156 2yyo (A) 28 140 33.00 0.064 0.81 0.607712 0.74

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_132994)

Species Accession Gene Product
Brugia malayi Bm1_10655   SPRY domain containing protein
Brugia malayi Bm1_14940   RE37682p
Caenorhabditis elegans CELE_F18H3.1   Protein F18H3.1
Drosophila melanogaster Dmel_CG7785   CG7785 gene product from transcript CG7785-RA
Echinococcus granulosus EgrG_000656300   chronic lymphocytic leukemia deletion region
Echinococcus multilocularis EmuJ_000656300   chronic lymphocytic leukemia deletion region
Homo sapiens ENSG00000123178   SPRY domain containing 7
Mus musculus ENSMUSG00000021930   SPRY domain containing 7
Onchocerca volvulus OVOC2304  
Schistosoma japonicum Sjp_0311430   expressed protein
Schistosoma mansoni Smp_194240   hypothetical protein
Schmidtea mediterranea mk4.005776.02  
Schmidtea mediterranea mk4.012058.02  

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Rattus norvegicus Dehydrogenase/reductase SDR family member 9 319 aa 34.7% 294 aa Compounds References
Callithrix jacchus 17-beta-hydroxysteroid dehydrogenase type 1 314 aa 26.3% 266 aa Compounds References
Macaca mulatta Hydroxysteroid 11-beta dehydrogenase 1 140 aa 20.0% 145 aa Compounds References
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier OVOC2304 (Onchocerca volvulus),
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