Detailed view for OVOC10821

Basic information

TDR Targets ID: 986269
Onchocerca volvulus,
Source Database / ID:  Wormbase Parasite  

pI: 9.2556 | Length (AA): 185 | MW (Da): 21649 | Paralog Number: 0

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF04791  

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

No model available for this protein in Modbase.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_128525)

Species Accession Gene Product
Arabidopsis thaliana AT5G65290   LMBR1-like membrane protein
Brugia malayi Bm1_42180   LMBR1-like conserved region family protein
Caenorhabditis elegans CELE_C47G2.4   Protein C47G2.4
Cryptosporidium hominis Chro.70354   Dkfzp434h2226-prov protein
Cryptosporidium parvum cgd7_3150   eukaryote specific membrane proteins signal peptide plus 8 transmembrane domain
Dictyostelium discoideum DDB_G0281669   hypothetical protein
Dictyostelium discoideum DDB_G0284019   hypothetical protein
Drosophila melanogaster Dmel_CG8135   CG8135 gene product from transcript CG8135-RA
Echinococcus granulosus EgrG_000482300   LMBR1 domain containing protein 2
Entamoeba histolytica EHI_049750   hypothetical protein, conserved
Echinococcus multilocularis EmuJ_000482300   LMBR1 domain containing protein 2
Homo sapiens 92255   LMBR1 domain containing 2
Leishmania braziliensis LbrM.30.0630   hypothetical protein, conserved
Leishmania donovani LdBPK_300570.1   LMBR1-like membrane protein, putative
Leishmania infantum LinJ.30.0570   hypothetical protein, conserved
Leishmania major LmjF.30.0550   hypothetical protein, conserved
Leishmania mexicana LmxM.29.0550   hypothetical protein, conserved
Mus musculus ensembl-mmu:ENSMUSG00000039704   LMBR1 domain containing 2
Oryza sativa 4340506   Os06g0218900
Oryza sativa 4330787   Os02g0758100
Onchocerca volvulus OVOC10821  
Schmidtea mediterranea mk4.001622.08  
Trypanosoma brucei gambiense Tbg972.6.1700   hypothetical protein, conserved
Trypanosoma brucei Tb927.6.1980   LMBR1-like membrane protein, putative
Trypanosoma congolense TcIL3000_0_33880   LMBR1-like membrane protein, putative
Trypanosoma congolense TcIL3000_6_1560   hypothetical protein, conserved
Trypanosoma cruzi TcCLB.504071.70   LMBR1-like membrane protein, putative
Trichomonas vaginalis TVAG_333140   conserved hypothetical protein
Trichomonas vaginalis TVAG_208790   conserved hypothetical protein
Trichomonas vaginalis TVAG_351520   conserved hypothetical protein

Essentiality

OVOC10821 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb927.6.1980 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb927.6.1980 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (6 days) alsford
Tb927.6.1980 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb927.6.1980 Trypanosoma brucei significant gain of fitness in differentiation of procyclic to bloodstream forms alsford
Show/Hide essentiality data references
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier OVOC10821 (Onchocerca volvulus),
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