Detailed view for OVOC6006

Basic information

TDR Targets ID: 986423
Onchocerca volvulus,
Source Database / ID:  Wormbase Parasite  

pI: 5.6179 | Length (AA): 1307 | MW (Da): 146708 | Paralog Number: 1

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF12695  

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 5 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
34 309 4krx (A) 19 306 21.00 0.034 0.97 1.02819 0.54
85 299 3o4h (A) 344 557 18.00 0.031 1 0.88854 -0.07
102 189 2e3j (A) 28 114 29.00 0.54 1 0.682365 -0.5
102 199 3qh4 (A) 82 182 31.00 0.054 1 0.684111 -1.3
242 279 3doh (A) 312 347 50.00 0.2 0.31 0.478635 1.16

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_131360)

Species Accession Gene Product
Brugia malayi Bm1_12180   Protein C20orf22
Caenorhabditis elegans CELE_Y97E10AL.2   Protein Y97E10AL.2
Drosophila melanogaster Dmel_CG15111   CG15111 gene product from transcript CG15111-RB
Echinococcus granulosus EgrG_000217800   monoacylglycerol lipase abhd12
Echinococcus multilocularis EmuJ_000217800   monoacylglycerol lipase abhd12
Homo sapiens ENSG00000100997   abhydrolase domain containing 12
Loa Loa (eye worm) LOAG_11300   hypothetical protein
Loa Loa (eye worm) LOAG_15136   hypothetical protein
Loa Loa (eye worm) LOAG_15821   hypothetical protein
Mus musculus ENSMUSG00000032046   abhydrolase domain containing 12
Onchocerca volvulus OVOC6094  
Onchocerca volvulus OVOC6006  
Schistosoma japonicum Sjp_0205340   IPR000073,Alpha/beta hydrolase fold-1;IPR002345,Lipocalin,domain-containing
Schistosoma mansoni Smp_010280   family S9 unassigned peptidase (S09 family)
Schmidtea mediterranea mk4.022575.00  
Schmidtea mediterranea mk4.022423.00  
Schmidtea mediterranea mk4.020135.00  

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Mus musculus abhydrolase domain containing 12 Compounds References
Homo sapiens abhydrolase domain containing 12 Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier OVOC6006 (Onchocerca volvulus),
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