Detailed view for OVOC2386

Basic information

TDR Targets ID: 986924
Onchocerca volvulus,
Source Database / ID:  Wormbase Parasite  

pI: 9.5045 | Length (AA): 442 | MW (Da): 50623 | Paralog Number: 0

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF10230  

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 4 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
21 325 1hkh (A) 2 279 12.00 0.000009 0.41 0.958978 -0.15
27 327 5olu (A) 5 308 16.00 0.00000012 0.39 1.00878 0.21
30 323 3c5v (A) 65 367 16.00 0.26 0.88 0.948441 0.29
251 326 3bdi (A) 132 206 12.00 0.0003 0.14 0.303807 0.25

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_128547)

Species Accession Gene Product
Arabidopsis thaliana AT3G11620   hypothetical protein
Brugia malayi Bm1_20610   LP01162p
Candida albicans CaO19.4398   weak similarity to S. cerevisiae YPR147C
Candida albicans CaO19.11876   weak similarity to S. cerevisiae YPR147C
Caenorhabditis elegans CELE_F11C1.4   Protein F11C1.4
Caenorhabditis elegans CELE_F26A3.1   Protein F26A3.1
Caenorhabditis elegans CELE_F11C1.10   Protein F11C1.10
Dictyostelium discoideum DDB_G0286581   hypothetical protein
Drosophila melanogaster Dmel_CG9186   CG9186 gene product from transcript CG9186-RB
Entamoeba histolytica EHI_146190   hypothetical protein
Entamoeba histolytica EHI_197270   hypothetical protein, conserved
Homo sapiens ENSG00000118961   chromosome 2 open reading frame 43
Leishmania braziliensis LbrM.26.0250   hypothetical protein, conserved
Leishmania donovani LdBPK_260210.1   Uncharacterised conserved protein (DUF2305), putative
Leishmania infantum LinJ.26.0210   hypothetical protein, conserved
Leishmania major LmjF.26.0220   hypothetical protein, conserved
Leishmania mexicana LmxM.26.0220   hypothetical protein, conserved
Loa Loa (eye worm) LOAG_06304   hypothetical protein
Loa Loa (eye worm) LOAG_14961   hypothetical protein
Mus musculus ENSMUSG00000037669   RIKEN cDNA 1110057K04 gene
Oryza sativa 4325392   Os01g0958800
Onchocerca volvulus OVOC2386  
Saccharomyces cerevisiae YPR147C   hypothetical protein
Schmidtea mediterranea mk4.006826.03   UPF0554 protein C2orf43
Trypanosoma brucei gambiense Tbg972.7.1690   hypothetical protein, conserved
Trypanosoma brucei Tb927.7.1680   Uncharacterised conserved protein (DUF2305), putative
Trypanosoma cruzi TcCLB.508207.160   Uncharacterised conserved protein (DUF2305), putative
Trypanosoma cruzi TcCLB.507519.50   Uncharacterised conserved protein (DUF2305), putative

Essentiality

OVOC2386 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb927.7.1680 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb927.7.1680 Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb927.7.1680 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb927.7.1680 Trypanosoma brucei significant loss of fitness in differentiation of procyclic to bloodstream forms alsford
Show/Hide essentiality data references
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Schizosaccharomyces pombe 972h- Casein kinase II subunit alpha 332 aa 27.8% 320 aa Compounds References
Plasmodium falciparum (isolate 3D7) Cell division control protein 2 homolog 288 aa 40.1% 302 aa Compounds References
Xenopus laevis Aurora kinase B-B 368 aa 25.5% 318 aa Compounds References
Xenopus laevis Aurora kinase B-A 361 aa 26.1% 310 aa Compounds References
Oryctolagus cuniculus Cyclin-dependent kinase 4 189 aa 39.6% 197 aa Compounds References
Rattus norvegicus Mitogen-activated protein kinase 1 358 aa 33.8% 302 aa Compounds References
Zea mays Casein kinase II alpha 332 aa 26.4% 307 aa Compounds References
Rattus norvegicus MAP kinase p38 alpha 360 aa 31.4% 309 aa Compounds References
Patiria pectinifera Cdc2 300 aa 38.9% 303 aa Compounds References
Homo sapiens Cyclin-dependent kinase 1/cyclin B1 297 aa 38.3% 303 aa Compounds References
Rattus norvegicus Cell division protein kinase 5 292 aa 41.9% 301 aa Compounds References
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier OVOC2386 (Onchocerca volvulus),
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