Detailed view for OVOC4659

Basic information

TDR Targets ID: 987414
Onchocerca volvulus, Palmitoyltransferase homolog
Source Database / ID:  Wormbase Parasite  

pI: 6.9553 | Length (AA): 180 | MW (Da): 20369 | Paralog Number: 0

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00023  
PF01529  
PF12796  

Gene Ontology

Mouse over links to read term descriptions.
GO:0008270   zinc ion binding  
GO:0005515   protein binding  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 5 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
3 224 5et1 (A) 74 328 33.00 0 1 0.70175 -0.43
50 194 2v5q (C) 31 139 44.00 0 1 0.408982 0.59
69 139 1k1a (A) 129 203 35.00 0 0.9 0.516799 -0.41
169 232 6iyb (B) 49 112 27.00 0.054 0.48 0.532502 -1.25
376 533 6bmn (A) 124 263 34.00 0 0.17 0.193748 1.85

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_127697)

Species Accession Gene Product
Arabidopsis thaliana AT2G14255   Ankyrin repeat family protein with DHHC zinc finger domain
Arabidopsis thaliana AT5G20350   S-acyltransferase TIP1
Brugia malayi Bm1_38135   DHHC zinc finger domain containing protein
Candida albicans CaO19.12414   ankyrin repeat-containing protein
Candida albicans CaO19.4950   ankyrin repeat-containing protein
Caenorhabditis elegans CELE_D2021.2   Protein DHHC-14, isoform B
Caenorhabditis elegans CELE_H32C10.3   Protein DHHC-13
Dictyostelium discoideum DDB_G0275097   hypothetical protein
Dictyostelium discoideum DDB_G0275149   hypothetical protein
Dictyostelium discoideum DDB_G0287729   hypothetical protein
Drosophila melanogaster Dmel_CG6618   CG6618 gene product from transcript CG6618-RA
Drosophila melanogaster Dmel_CG6017   Huntingtin-interacting protein 14
Echinococcus granulosus EgrG_000495000   Ankyrin and zinc finger DHHC domain containing protein
Echinococcus granulosus EgrG_000972100   Ankyrin
Entamoeba histolytica EHI_169960   hypothetical protein, conserved domain containing
Echinococcus multilocularis EmuJ_000972100   Ankyrin
Echinococcus multilocularis EmuJ_000495000   Ankyrin and zinc finger DHHC domain containing protein
Homo sapiens ENSG00000186908   zinc finger, DHHC-type containing 17
Homo sapiens ENSG00000177054   zinc finger, DHHC-type containing 13
Loa Loa (eye worm) LOAG_03617   hypothetical protein
Mus musculus ENSMUSG00000030471   zinc finger, DHHC domain containing 13
Mus musculus ENSMUSG00000035798   zinc finger, DHHC domain containing 17
Neospora caninum NCLIV_034970   hypothetical protein
Oryza sativa 4328524   Os02g0184000
Oryza sativa 4350702   Os11g0549700
Oryza sativa 4341648   Os06g0644500
Onchocerca volvulus OVOC4659   Palmitoyltransferase homolog
Saccharomyces cerevisiae YOR034C   Akr2p
Saccharomyces cerevisiae YDR264C   Akr1p
Schistosoma japonicum Sjp_0022010   Probable palmitoyltransferase ZDHHC13, putative
Schistosoma mansoni Smp_136530   ankyrin repeat-containing
Schmidtea mediterranea mk4.000176.00   Palmitoyltransferase
Schmidtea mediterranea mk4.002365.06   Palmitoyltransferase
Schmidtea mediterranea mk4.000119.11   Palmitoyltransferase
Toxoplasma gondii TGME49_272320   DHHC zinc finger domain-containing protein

Essentiality

OVOC4659 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
TGME49_272320 Toxoplasma gondii Essentiality uncertain sidik
Show/Hide essentiality data references
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier OVOC4659 (Onchocerca volvulus), Palmitoyltransferase homolog
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