Detailed view for OVOC3642
Basic information
Onchocerca volvulus,
Source Database / ID: Wormbase Parasite
pI: 6.5381 |
Length (AA): 850 |
MW (Da): 93365 |
Paralog Number:
8169
Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Network
Pfam domains
Gene Ontology
Metabolic Pathways
Structural information
Modbase 3D models:
PDB Structures:
Expression
Orthologs
Essentiality
Phenotypes and Validation (curated)
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Annotated validation
Associated compounds / Druggability
Known modulators for this target
Predicted associations
By orthology with druggable targets
By sequence similarity to non orthologous druggable targets
| Species | Target | Length | Identity | Alignment span | Linked Drugs | Reference |
|---|---|---|---|---|---|---|
| Mycoplana ramosa | Acetylpolyamine aminohydrolase | 341 aa | 27.4% | 329 aa | Compounds | References |
| Rattus norvegicus | Histone deacetylase | 328 aa | 54.3% | 267 aa | Compounds | References |
Obtained from network model
Assayability
Assay information
Reagent availability
Bibliographic References