Detailed view for OVOC11591

Basic information

TDR Targets ID: 988590
Onchocerca volvulus,
Source Database / ID:  Wormbase Parasite  

pI: 8.5618 | Length (AA): 519 | MW (Da): 56674 | Paralog Number: 0

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 10

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00378  

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Metabolic Pathways

Peroxisome (KEGG)

Structural information

Modbase 3D models:

There are 3 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
22 300 4og1 (A) 1 267 31.00 0 1 1.23971 -0.12
29 298 1dci (A) 55 321 47.00 0 1 1.51981 -0.83
34 219 3isa (A) 12 178 31.00 0.000000049 1 1.00044 -0.91

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_129459)

Species Accession Gene Product
Arabidopsis thaliana AT5G43280   delta(3,5),delta(2,4)-dienoyl-CoA isomerase 1
Brugia malayi Bm1_35505   enoyl-CoA hydratase/isomerase family protein
Candida albicans CaO19.14122   enoyl-CoA hydratase/isomerase family protein similar to N. crassa sequence (CAD21495)
Candida albicans CaO19.6830   enoyl-CoA hydratase/isomerase family protein similar to N. crassa sequence (CAD21495)
Caenorhabditis elegans CELE_Y25C1A.13   Protein Y25C1A.13
Caenorhabditis elegans CELE_F58A6.1   Protein F58A6.1
Dictyostelium discoideum DDB_G0282261   Delta-Delta-dienoyl-CoA isomerase
Drosophila melanogaster Dmel_CG9577   CG9577 gene product from transcript CG9577-RA
Homo sapiens ENSG00000104823   enoyl CoA hydratase 1, peroxisomal
Leishmania braziliensis LbrM.18.0640   peroxisomal enoyl-coa hydratase, putative
Leishmania donovani LdBPK_180580.1   peroxisomal enoyl-coa hydratase, putative
Leishmania infantum LinJ.18.0580   peroxisomal enoyl-coa hydratase, putative
Leishmania major LmjF.18.0580   peroxisomal enoyl-coa hydratase, putative
Leishmania mexicana LmxM.18.0580   peroxisomal enoyl-coa hydratase, putative
Loa Loa (eye worm) LOAG_07056   enoyl-CoA hydratase/isomerase
Mycobacterium leprae ML0120c   Possible enoyl-CoA hydratase EchA21 (enoyl hydrase) (unsaturated acyl-coA hydratase) (crotonase)
Mus musculus ENSMUSG00000053898   enoyl coenzyme A hydratase 1, peroxisomal
Mycobacterium tuberculosis Rv3774   Possible enoyl-CoA hydratase EchA21 (enoyl hydrase) (unsaturated acyl-CoA hydratase) (crotonase)
Neospora caninum NCLIV_054880   Short chain enoyl-CoA hydratase (EC 4.2.1.17), related
Oryza sativa 4327232   Os01g0925200
Onchocerca volvulus OVOC11591  
Schmidtea mediterranea mk4.013378.00   Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial
Trypanosoma cruzi TcCLB.511277.210   peroxisomal enoyl-coa hydratase, putative
Toxoplasma gondii TGME49_310830   enoyl-CoA hydratase/isomerase family protein

Essentiality

OVOC11591 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
mtu3841 Mycobacterium tuberculosis non-essential nmpdr
CELE_F58A6.1 Caenorhabditis elegans slow growth wormbase
CELE_Y25C1A.13 Caenorhabditis elegans larval arrest wormbase
TGME49_310830 Toxoplasma gondii Probably non-essential sidik
Show/Hide essentiality data references
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Rattus norvegicus Solute carrier family 2, facilitated glucose transporter member 1 492 aa 41.2% 466 aa Compounds References
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier OVOC11591 (Onchocerca volvulus),
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